Background: Many foods can cause food allergies. Grapple® is just one of many new fruits recently introduced into grocery stores. Objective: To describe 2 unique patients with food allergies after consuming a unique food, a Grapple. Methods: Commercial skin prick testing, fresh fruit prick-prick and radioallergosorbent testing were used to characterize the food allergy reaction. Results: Clinical history and appropriate testing confirmed the Grapple food allergy. Conclusions: To our knowledge, these are the first 2 case reports of food allergy to a new fruit called Grapple. These cases illustrate the importance of consumer labeling laws and careful identification of component ingredients by food-allergic individuals.