Immunotherapy for allergic diseases give rise to questions about when a decision must be taken to define the number of extracts to be used in a single treatment. This represents a long-lasting matter of debate between American and European allergists, which seems to be without real solution. Through the use of extract-based versus molecule-based diagnostic approaches we suggest a possible solution to this controversial issue. We used four model patients previously tested with allergenic extracts and later on selected on the basis of a panel of available allergenic molecules. Their reactivity patterns in term of extracts and molecules were compared and the decision for allergenic extract immunotherapy was made choosing either the ‘classical’ approach or the molecular approach. From our study it seems that molecules could offer the solution to the ‘mixing’ issue of allergenic extracts. This innovative approach seems to provide a solution for both the American and the European approach.

1.
Bousquet J, Lockey R, Malling HJ: Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998;102(4 Pt 1):558–562.
2.
Adkinson NF Jr, Eggleston PA, Eney D, Goldstein EO, Schuberth KC, Bacon JR, Hamilton RG, Weiss ME, Arshad H, Meinert CL, Tonascia J, Wheeler B: A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med 1997;336:324–331.
3.
Malling HJ, Weeke B: EAACI position paper on immunotherapy. Allergy 1993;48(suppl 14):9–35.
4.
Joint Council of Allergy, Asthma and Immunology. Practice parameters for allergen immunotherapy. J Allergy Clin Immunol 1996;98(6 Pt 1):1001–1011.
5.
Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R: Recombinant marker allergens: diagnostic gatekeepers for the treatment of allergy. Int Arch Allergy Immunol 2002;127:259–268.
6.
Mari A: Multiple pollen sensitization: a molecular approach to the diagnosis. Int Arch Allergy Immunol 2001;125:57–65.
7.
Mari A: Skin test with a timothy grass (Phleum pratense) pollen extract vs IgE to a timothy extract vs IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data. Clin Exp Allergy 2003;33:43–51.
8.
Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O: Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 2005;116:608–613.
9.
Valenta R, Hayek B, Seiberler S, Bugajska-Schretter A, Niederberger V, Twardosz A, Natter S, Vangelista L, Pastore A, Spitzauer S, Kraft D: Calcium-binding allergens: from plants to man. Int Arch Allergy Immunol 1998;117:160–166.
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