Background: The development of allergies is a complex in which both composition and influence of the intestinal flora play an important role. We observed in earlier studies that the presence of an orally administered probiotic Escherichia coli strain in the intestine stimulated both a serum and local antibody response, decreased the presence of pathogens, the number of infections and the need for antibiotics. Methods: The preventive effect of oral colonization after birth with a probiotic E. coli strain was assessed by evaluating the results of a questionnaire both 20 years (150 full-term infants) and 10 years (77 preterm infants) after colonization. Results: Differences in occurrence of allergies in colonized and control subjects were statistically significant both after 10 and 20 years (p < 0.01). Specific serum IgE antibodies confirmed the presence of allergies in 100% of 10-year-old and 91% of 20-year-old patients with clinical symptoms of allergy. Ten years after colonization, the occurrence of repeated infections was significantly lower in colonized subjects than it was in controls (p < 0.01); 20 years later, no differences were found in these groups. Conclusions: Intentional colonization of the intestine with E. coli after birth (offering the advantage of the first colonizer) was found to decrease the incidence of allergies and repeated infections in later life.

Keywords:
Escherichia coli colonization, neonatal, Allergy, long-term prevention, Probiotics
1.
Lari AK, Gold F, Borderon JC, Laugier J, Lafont JP: Implantation and in vivo antagonistic effects of antibiotic-susceptible Escherichia coli strains administered to premature newborns. Biol Neonate 1990;58:73–78.
2.
Kalliomaki M, Salminen S, Arvilommi H, Koro P, Koskinen P, Isolauri E: Probiotics in primary prevention of atopic disease: A randomized placebo-controlled trial. Lancet 2001;357:1076–1079.
3.
Lodinova-Zadnikova R, Slavikova M, Tlaskalova-Hogenova H, Adlerberth I, Hanson LA, Wold A, Carlsson B, Svanborg C, Mellander L: The antibody response in breast-fed and non-breast-fed infants after artificial colonisation of the intestine with E. coli 083. Pediatr Res 1991;29:31–39.
4.
Lodinova-Zadnikova R, Tlaskalova H, Bartakova Z: The antibody response in infants after colonisation of the intestine with E. coli 083. Artificial colonisation used as prevention against nosocomial infections. Adv Exp Med Biol 1991;310:329–333.
5.
Tlaskalová-Hogenova H, Tuckova L, Lodinova-Zadnikova R, Stepankova R, Cukrowska B, Funda DP et al: Mucosal immunity: Its role in defense in allergy. Int Arch Allergy Immunol 2002;128:77–89.
6.
Cukrowska B, Lodinova-Zadnikova R, Enders C, Sonnenborn U, Schulz J, Tlaskalova-Hogenova H: Specific proliferative and antibody responses of premature infants to intestinal colonization with non-pathogenic probiotic E. coli strain Nissle 1917. Scand J Immunol 2002;55:204–209.
© 2003 S. Karger AG, Basel
2003
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