The effects of lactic dehydrogenase virus (LDV) infection on allergic eosinophil reaction and IL–5 gene expression were studied. LDV infection suppressed antigen–induced eosinophil recruitment into the peritoneal cavity in sensitized mice. The elevation of IL–5 gene expression in the spleen and mesenteric lymph nodes 6 h after ovalbumin challenge was significantly suppressed in LDV–infected mice compared with uninfected (control) mice. The expression of the interferon–γ and IL–2 genes in the spleen, but not in mesenteric lymph nodes, was significantly suppressed in LDV–infected mice compared with control mice. The present results suggest, that suppression of IL–5 gene expression by LDV infection may not be mediated by a mutual inhibitory mechanism between Th1 and Th2 cells.

Keywords:
Eosinophil, IL–5, Lactic dehydrogenase virus
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