In order to show the surface expression of FcεRI on human epidermal Langerhans cells (LC), we examined monomeric IgE binding to LC. We demonstrated that the majority of epidermal LC were able to bind monomeric IgE. IgE binding to LC could neither be prevented by preincubation of the tissue with monoclonal antibodies (mAb) against either FcεRII/CD23 or FcγRII/CD32, nor by the addition of lactose, but could be entirely abrogated by preincubation with the anti-FcεRI mAb 15-1. These data show that epidermal LC express FcεRI molecules.

Keywords:
Langerhans cell, IgE, FcεRI, Monoclonal antibody
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© 1994 S. Karger AG, Basel
1994
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