IL-5 is a homodimeric glycoprotein that promotes proliferation and differentiation of activated B cells, and controls the production and functions of some other hematopoietic cells, such as Ly-1(CD5)+ B cells, eosinophils and basophils. In humans, IL-5 acts as a differentiation and growth factor for eosinophils, and is the major cytokine involved in the production of eosinophilia. IL-5 acts on its target cells through the specific receptor that is composed of two polypeptide chains, a and b. The α-chain is unique to IL-5, while the β-chain is common to IL-5 receptor, IL-3 receptor and granulocyte-macrophage colony stimulating factor (GM-CSF) receptor.

Keywords:
IL-5, Receptor, B cell, Eosinophil
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© 1994 S. Karger AG, Basel
1994
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