Using guinea pig models of nasal allergy, we investigated the role of PAF in mucosal hypersensitivity to topical histamine challenge. We found that the histamine sensitivity was significantly increased by nasal allergen challenge in actively sensitized guinea pigs, and the occurrence of histamine hypersensitivity was inhibited by pretreatment of anti-PAF agent (SM10661, 10 mg/kg, i.p.). Also, the histamine sensitivity was further increased by a single nasal challenge with PAF in actively sensitized guinea pigs. The histamine hypersensitivity was induced by repeated topical challenges with PAF in nonsensitized guinea pigs. Therefore, we believe that PAF plays an important role in hypersensitivity to histamine in nasal allergy.

Keywords:
Platelet-activating factor, Histamine, Hypersensitivity, Anti-PAF agent, SM10661
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© 1993 S. Karger AG, Basel
1993
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