..., type II 3β-HSD gene from 4 girls who were diagnosed as NC3β-HSD deficient, based on the adrenal steroidogenic responses to ACTH, was analyzed to determine whether NC3β-HSD deficiency was an allelic variant of classical 3β-HSD deficiency by polymerase chain reaction-single strand conformation...

... that insulin might induce a conformational change in responsive tissues is considered and how such need not include nuclear events. An alter native suggestion would be for insulin to induce a small rise in intra cellular pH. Such would favour many pH-sensitive reactions and is indicated by studies...