.... The inter individual variation of u-GH excretion within the same Tanner stage was considerable and approximately double the intra individual variation. The day-to-day variation could be further reduced by collection of three consecutive urine samples. The variations were larger if night samples instead...

... increases IGF-I into the normal range, although there is a large variation. Excessively high (supranormal) GH-induced IGF-I levels are associated with increased prevalence of side effects in adults with GHD. Consequently, at most centres, GH doses are titrated according to IGF-I levels in GHD adults...