...Catherina T. Pinnaro; Blake Irvin Zimmerman; Kelli K. Ryckman; Benjamin W. Darbro; Andrew W. Norris Introduction: The cause of increased diabetes mellitus (DM) risk in individuals with Turner syndrome (TS) is poorly understood. Parent-of-origin effects related to whether the maternal or paternal X...

... Turner Syndrome Working Group Introduction: Natural oestrogen administration as oral or transdermal 17β-estradiol is recommended for pubertal induction in girls with hypogonadism. However, suitable low-dose formulations are not consistently available globally. This questionnaire study aimed to identify...

...Carl-Joachim Partsch; Christof Land; Roland Werner Pfäffle; Karl Otfried Schwab; Heide Sommer; German PATRO-Board Introduction: Growth hormone (GH) treatment in children with growth hormone deficiency (GHD), short children born small for gestational age (SGA), and Turner syndrome (TS) is well...

...Maria Graciela Parra Villasmil; Kelli K. Ryckman; Andrew W. Norris; Catherina T. Pinnaro Introduction: Individuals with Turner syndrome (TS) are at increased risk of developing diabetes mellitus (DM). Currently, annual DM screening with hemoglobin A1c (HbA1c) with or without fasting blood glucose...

...)Experimental: testicular tissue cryopreservationRarely spontaneous pregnancyExperimental: ovarian tissue cryopreservation CAH, congenital adrenal hyperplasia; MRKH, Mayer-Rokitansky-Küster-Hauser; TS, Turner syndrome; KS, Klinefelter syndrome; GD, gonadal dysgenesis; PAIS, partial androgen insensivity...

...Tazim Dowlut-McElroy; Roopa Kanakatti Shankar Introduction: Turner syndrome (TS) is associated with primary ovarian insufficiency (POI) and most adolescents and young adults (AYA) with TS require treatment with hormone replacement therapy (HRT). International consensus guidelines are unclear...

...: In Turner syndrome (TS), fluorescent in situ hybridization (FISH) karyotyping offers an alternative to classical karyotyping. Objective: We tested the added value of FISH karyotyping from lymphocytes (mesodermal origin), buccal cells (ectodermal origin), and a rear-tongue smear (endodermal origin...

...Sanne van der Coelen; Janielle van der Velden; Sapthami Nadesapillai; Ron Peek; Didi Braat; Myra Schleedoorn; Kathrin Fleischer; Anke Oerlemans Introduction: Ovarian tissue cryopreservation (OTC) has proven to be effective in other patient groups, but the effectiveness in girls with Turner syndrome...

...Charleen I. Theroux; Victoria Elliott; Shanlee Davis; Canice E. Crerand; Jessica Kremen; Amy Tishelman; Christa Hutaff-Lee; Leena Nahata Introduction: Turner syndrome (TS) is associated with a high risk of primary ovarian insufficiency. Current guidelines recommend early fertility counseling...

...Eirene Alexandrou; Sarah Corathers; Iris Gutmark-Little; Lori Casnellie; Melissa Gerstle; Jonathan Tatum; Jane Khoury; Philippe Backeljauw Introduction: Turner syndrome (TS) results from a complete or partial loss of the X chromosome and affects 25–50 per 100,000 females. These individuals have...

...Nicole Sheanon; Deborah Elder; Jane Khoury; Lori Casnellie; Iris Gutmark-Little; Joseph Cernich; Phillipe F. Backeljauw Introduction: Adult women with Turner syndrome (TS) have a high prevalence of diabetes and β-cell dysfunction that increases morbidity and mortality, but it is unknown...

... Turner syndrome Childhood Growth hormone Near-adult height Final height Thelarche Prepuberty Puberty Safety Data collected at Extension study baseline included historical information from the Inter-study period such as illnesses, GH and/or estrogen treatment, concomitant medications...

... for a biosimilar recombinant human growth hormone (rhGH; somatropin, Omnitrope®; Sandoz), approved by the European Medicines Agency in 2006. We report safety and effectiveness data for patients with Turner syndrome (TS). Methods: The study population included infants, children, and adolescents with TS who received...

... height (AH) in Turner syndrome (TS). However, there are few studies comparing AH between treated patients and a concurrent untreated group. Objective: To assess the efficacy of GH treatment in improving AH in TS and to review previous published studies with treated and untreated groups. Participants...

...Shanlee Davis; Canice Crerand; Christa Hutaff-Lee; Talia Thompson; Amy Tishelman; Omar Samara; Hailey Umbaugh; Leena Nahata; Jessica Kremen Introduction: International Turner syndrome (TS) Clinical Practice Guidelines recommend screening for neurodevelopmental (ND) and mental health (MH) concerns...

...Roopa Kanakatti Shankar Turner syndrome (TS), characterized by the partial or complete absence of an X-chromosome, provides a unique insight into the role of the X-chromosome and the immune system. While women have a 10-fold higher incidence of autoimmune disease (AD) compared with men, the risk...

.... Results: As of November 2017, 6,009 patients from 298 centers across 14 countries were enrolled in PATRO Children. Overall, 57.7% of patients had growth hormone deficiency (GHD), 25.8% were born small for gestational age (SGA), and 4.8% had Turner syndrome (TS). In total, 84.1% were rhGH treatment naïve...

...Elizabeth Dabrowski; Rachel Jensen; Emilie K. Johnson; Reema L. Habiby; Wendy J. Brickman; Courtney Finlayson Background: Girls with Turner syndrome (TS) have a high incidence of primary ovarian insufficiency. Recent data show rates of spontaneous thelarche (ST) of 38% and spontaneous menarche (SM...

...Rabab Z. Jafri; Erin A. McNamara; Emma A. Snyder; Uzma Shah; Isani Singh; Frances J. Hayes; Angela E. Lin; Lynne L. Levitsky Background: Liver function test (LFT) abnormalities, which may reflect underlying pathophysiology, are a well-known feature of Turner syndrome. Less frequently, liver...

...Jung Min Ahn; Jung Hwan Suh; Ah Reum Kwon; Hyun Wook Chae; Ho-Seong Kim Aims: This study aimed to evaluate final adult height (AH) after recombinant human growth hormone (GH) treatment of girls with Turner syndrome (TS) and to elucidate the predicting factors for their growth response. Methods: We...