... is conserved in humans. This review will discuss our current knowledge in mouse as well as human pancreatic development and highlights some important transcription factors associated with human disease. The pancreatic buds contain undifferentiated precursor cells that are specified towards either...

... studies have focused on pancreas development. The objective was to characterize the cellular and molecular factors that control the differentiation of endocrine and exocrine cell types. Investigation of the role of transcription factors by using genetic approaches led to the discovery of key molecules...

... hormone deficiency are common and many are caused by transcription factor defects. Mouse models with orthologous mutations are invaluable for uncovering the molecular mechanisms that lead to problems in organ development and typical patient characteristics. We are using mutant mice defective...

.... Synthetic hexapeptides that stimulate GH release (GH-releasing peptides 1, 2 and 6) have been identified. Pituitary-specific transcription factors involved in the expression of the GH gene have been identified, the GHRH receptor gene has been cloned, as well as a number of somatostatin receptor genes...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cell lineage Pituitary development Transcription factors S y m p o siu m I...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gene expression Steroid receptors Transcription factors Atherosclerosis Peroxisome proliferation Retinoic acid...

... Transcription factors Ad4BP/SF-1 DAX-1 Adrenocortical carcinoma is rare, accounting for 0.02% of all annual cancers reported [ 1 ].Since it is a very aggressive tumor, early diagnosis is desirable; however, there is no specific tumor marker or characteristic radiophotographic findings, so...

... most of the MODY cases. These genes encode the enzyme glucokinase and the transcription factors hepatocyte nuclear factor 4α, hepatocyte nuclear factor 1α, insulin promoter factor-1, hepatocyte nuclear factor 1β and neuroD1. Additional MODY genes remain to be identified. The study of families with MODY...

... genetic counselling of affected families. By increasing our knowledge of thyroid development, we hope to uncover new perspectives of genetic screening and eventually of early in utero treatment. Congenital hypothyroidism Thyroid dysgenesis Hormone synthesis Thyroid development Transcription factors...

...Primus-E. Mullis Objective: Several genes encoding homeobox transcription factors are important for normal pituitary gland development and eventually for hormone production. Methods and Results: By interacting with each other on the basis of a distinct temporal and spatial expression pattern...

...Claude J. Migeon; Amy B. Wisniewski Over the past decade, knowledge of the genetic control of human sex differentiation has greately expanded our understanding of the developmental processes needed to form a male or female. The purpose of this review is to discuss how transcription factors...