... regarding the effect thyroid hormones (TH) have on proper mammalian brain development. Objective: To evaluate the prevalence of abnormalities of thyroid function in a cohort of children with RTT. Patients and Methods: Forty-five consecutive Caucasian girls (mean age: 8.6 ± 5.3 years, range: 2.0-26.1...

...Ahmet Anık; Simone Kersseboom; Korcan Demir; Gönül Çatlı; Uluç Yiş; Ece Böber; Alies van Mullem; Ramona E.A. van Herebeek; Semra Hız; Ayhan Abacı; Theo J. Visser Background/Aims: Monocarboxylate transporter 8 (MCT8) is essential for thyroid hormone (TH) transport in the brain. Mutations in MCT8...

...Gloria S. Romero; Dietrich A. Stephan; Mark A. Sperling; Ram K. Menon Impairment of growth is a hallmark of hypothyroidism in animals. The ability of the thyroid hormone-thyroid hormone receptor complex to regulate gene transcription may be relevant to the growth impairment associated...

...C. Jaffiol; F. de Boisvilliers; L. Baldet; J. Torresani The syndromes of thyroid hormone resistance may affect overall or only some tissues. The generalized resistance is an inherited disease which involves a familial eumetabolic or hypometabolic goiter, increased free thyroid hormones with normal...

...T. Maruo; K. Katayama; E.R. Barnea; M. Mochizuki We have previously demonstrated that thyroid hormone synergizes with follicle-stimulating hormone (FSH) to exert stimulatory effects on granulosa cell differentiation and function, suggesting that it plays a physiological role in amplifying FSH...

...Ze Huang; Song Guang Ren; M. Medardo Burgueno; Mercedes Uriarte; Hernan B. Garcia; Kevin M. Barnes; Saul Malozowski; Fernando G. Cassorla; Gordon B. Cutler, Jr To examine the potential role of epidermal growth factor (EGF) in mediating the effects of thyroid hormone on linear growth, we measured...

... modifying cyclic AMP mediate increased transcription of TSH-β through interacting with upstream regulatory elements. Thyroid hormone, TRH and developmental factors also regulate the branching pattern and relative sialylation of TSH carbohydrate chains, which may affect TSH action in vitro and in vivo...

... and EGF receptor concentrations are modulated by thyroid hormones, estrogen, testosterone and growth hormone, suggesting that selected growth and developmental actions of thyroid and steroid hormones may be mediated by EGF 2 12 2008 © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage...

... the same inhibitory effects as the dose of T 3 used. 29 11 1979 23 05 1980 25 11 2008 Thyroid hormone Thyrotropin Thyrotropin-releasing hormone Pituitary Hormone Res. 13: 48-56 (1980) Comparison of Time-Dependent and Dose-Dependent Inhibitory Activity of T3 and T4 on TSH...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Thyroid hypoplasia Congenital hypothyroidism Williams syndrome Ultrasonography Thyroid hormone Thyrotropin-stimulating hormone Hypothyroidism On admission, the physical examination showed...

...Theo J. Visser Background: Cellular uptake and release of thyroid hormone are mediated by transporters. Among these, monocarboxylate transporter 8 (MCT8) shows particularly high activity towards the active thyroid hormone 3,3′,5-triiodothyronine (T 3 ). MCT8 is expressed in different tissues...

... with anti-thyroid treatment. This change of OPG level was associated with thyroid hormone free T4 (r = 0.175, p = 0.038) but not with free T3 (r = 0.164, p = 0.052) and TSH (r = 0.046, p = 0.59). Additionally, there was a negative correlation between OPG and PTH (r = –0.37, p = 0.0001). In stepwise...

...) which are transferred from the maternal into the fetal compartment, leading to stimulation of the fetal thyroid by activation of the TSH receptor. This leads to an increase in thyroid hormone secretion, and as a consequence, to thyrotoxicosis first in utero and then postnatally until the maternal...

... cartilage is invaded by blood vessels and bone cells that remodel the newly formed cartilage into bone tissue. This process of longitudinal bone growth is governed by a complex network of endocrine signals, including growth hormone, insulin-like growth factor I, glucocorticoid, thyroid hormone, estrogen...

... contributions from glucocorticoids (GC) and thyroid hormone (T 3 ). The somatomedin hypothesis proposed that GH stimulates hepatic IGF-I production, which then regulates growth via IGF-I receptor expressing chondrocytes in an endocrine fashion. Recent studies indicate that locally acting IGF-I is a key...

...T. Siebler; H. Robson; S.M. Shalet; G.R. Williams Thyroid hormone (T 3 ) plays a key role in normal skeletal development, linear growth and the acquisition and maintenance of bone mass. Childhood hypothyroidism is characterized by growth arrest, delayed bone age and epiphyseal dysgenesis...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Thyroid hormone Hypoxia 2,3-Bisphosphoglycerate Bisphosphoglycerate...

... Acad Sci USA 1995;92:5510–5514. 4. Zhang J, Lazar MA: The mechanism of action of thyroid hormones. Annu Rev Physiol 2000;62:439–466. 5. Castellà-Escolà J, Montoliu L, Pons G, Puigdomenech P, Cohen-Solal M, Carreras J, Rigau J, Climent F: Sequence of rat skeletal muscle phosphoglycerate mutase...

...Norio Ishikawa; Toshiaki Tanaka; Kinya Hashimoto; Masaki Wada Objective and Methods: The effect of thyroid hormone on human growth and maturation is considered ‘permissive’. To evaluate the effect of a prolonged thyroid hormone defect, especially in the pubertal period, a woman with untreated...