.... Optimal screening for differentiated thyroid cancer (DTC) in CCS post-RT remains controversial. We assessed the outcome of thyroid ultrasound (US) surveillance in CCS exposed to RT. Methods: 306 CCS were surveilled with thyroid US between 2002–2021. Surveillance was dependent on age at the time of primary...

...Kara J. Connelly; Julie J. Park; Stephen H. LaFranchi The history of the thyroid dates from 2697 BCE when the “Yellow Emperor” Hung Ti described the use of seaweed to treat goiter. The English name “thyroid” was coined by Thomas Wharton in 1656 from the Greek word for a shield. Bernard Courtois...

... profiling for the evaluation of indeterminate pediatric thyroid nodules is unclear. We aimed to assess pediatric cases with indeterminate thyroid fine-needle aspiration (FNA) alongside clinicopathologic features and mutational analysis. Methods: A retrospective review of 126 patients with indeterminate...

... by constitutional variants in PTEN . Several guidelines recommend thyroid screening, beginning at the pediatric age at the time of PHTS diagnosis; however, the benefits of early surveillance has not been well defined. Methods: We conducted a retrospective investigation of patients followed up at the Children’s...

...Panudda Srichomkwun; Osnat Admoni; Samuel Refetoff; Liat de Vries Background: Congenital hypothyroidism (CH) is a common endocrine disorder in newborns. The cause of CH is thyroid dysgenesis in 80-85% of patients. Paired box gene 8 (PAX8) is a thyroid transcription factor that plays an important...

...Helton Estrela Ramos; Magnus Régios Dias da Silva; Aurore Carré; Joaquim Custódio Silva Jr.; Rolf Matias Paninka; Taise Lima Oliveira; Elodie Tron; Mireille Castanet; Michel Polak Introduction: Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role...

...A. Ciresi; V. Guarnotta; M.C. Amato; C. Giordano Background/Aim: The significance of changes in thyroid function in children during growth hormone (GH) treatment remains uncertain. We aimed to evaluate the impact of GH replacement on thyroid status in children with idiopathic GH deficiency (GHD...

...D. Tessaris; A. Corrias; P. Matarazzo; L. De Sanctis; M. Wasniewska; M.F. Messina; M.C. Vigone; R. Lala Background: To date, there is no agreement about the frequency or the features of thyroid abnormalities in McCune-Albright syndrome (MAS). The aim of our study was to detect thyroid abnormalities...

...Dominique Luton; Elie Azria; Michel Polak; Aurore Carré; Edith Vuillard; Anne Lise Delezoide; Jean Guibourdenche Background/Aims: A mild increase in thyrotropin (thyroid-stimulating hormone; TSH) is common among Down syndrome patients but is rarely detected by neonatal screening at birth. We...

...Claudia Brufani; Melania Manco; Valerio Nobili; Danilo Fintini; Fabrizio Barbetti; Marco Cappa Background/Aims: Elevated thyroid-stimulating hormone (TSH) concentrations in association with normal/slightly elevated free triiodothyronine (fT 3 ) and/or free thyroxine (fT 4 ) have been consistently...

...Michel Polak Background: Advances in prenatal imaging techniques and in fetal hormonology now allow for identification of disorders of thyroid function in the fetus. These can potentially be treated in utero by giving drugs to the mother. Aims: This review examines the feasibility of in utero...

...Scott A. Rivkees Background/Aims: Graves’ disease (GD) is the most common cause of thyrotoxicosis in children and adolescents. Caused by immunologic stimulation of the thyroid-stimulating hormone receptor, lasting remission occurs in only a minority of pediatric patients with GD, including children...

...Ingemar Swenne; Mats Stridsberg; Barbro Thurfjell; Agneta Rosling Aim: Circulating thyroid hormone concentrations are influenced by nonthyroidal disease and changes in nutritional status. We studied thyroid hormones as possible indicators of nutrition in adolescent girls with eating disorders...

... assigned to receive either 12 months of IFN therapy, or to 6 months of observation followed by 6 months of IFN therapy. The thyroid functional and immunological status was checked every other month during and after treatment. Before treatment, antithyroid antibodies were found in 6 patients (7.5%). Two...

... prominent abnormalities occur in the thyroid, gonadal, and somatomedin axes. Clinical manifestations of these abnormalities are growth failure in children, which is one of the most sensitive indicators of disease progression, and a wasting syndrome in adults and children. Although there are case reports...

...David Wynford-Thomas Tumours of the thyroid follicular cell are proving to be one of the most informative models for ‘dissecting’ the molecular genetics of multi-stage human tumorigenesis. Early thyroid tumour development is closely correlated with mutation of five alternative genes, ras, ret, trk...

...Aldo Pinchera; Stefano Mariotti; Giuseppe Barbesino; Riccardo Bechi; Paolo Sansoni; Umberto Fagiolo; Andrea Cossarizza; Claudio Franceschi Ageing is associated with the appearance of several serum autoantibodies, including thyroid autoantibodies. The biological and clinical significance...

... overt thyroid disease, underwent r-interferon (IFN)-α-2a treatment (3-6 MU, 3 times/week) for 12 months. They were tested for thyroid function and for thyroid autoantibodies before (A), 6 (B) and 12 (C) months after the beginning of treatment and after 6 (D) months off therapy. Antithyroglobulin...

...F. Miot; F. Wilkin; S. Dremier; N. Uyttersprot; F. Lamy; J.E. Dumont; C. Maenhaut The activation of the cyclic AMP cascade in dog and human thyroid cells in primary culture induces the expression of differentiated gene expression, hyperfunction and proliferation. These programs are developed...

...M.I. Romano; M. Grattone; M.P. Karner; S. Moiguer; F. Tetelbaum; L.A. Romano; E. Illescas; R.P. Padin; F. Cueva; J.A. Burdman We investigated the relationship between the level of c -myc mRNA and histologic aggressiveness in thyroid tumors obtained at surgery. In thyroid carcinomas...