... hormone deficiency Recombinant human growth hormone treatment Adherence Systematic review Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in clinical health outcomes, several studies have shown that many children with growth hormone deficiency (GHD...

.... Noonan syndrome Growth hormone treatment Adult height Systematic review Clinical trials Table 1 Characteristics, results, and quality grading of non-randomised non-controlled trials and retrospective studies on final and near-final height after rhGH therapy in children with NS NS...

... standard. Empirical evidence shows that such trials are not always done well, and also that poor methodology is associated with biased findings. Consumers of the published literature need to be able to recognize which trials can be trusted. Systematic reviews and meta-analyses offer an organized approach...