... Growth hormone deficiency Small for gestational age Final height Response Growth hormone (GH) therapy (GHT) is registered for six defined growth disorders in Europe. Among these, GH deficiency (GHD) and short stature after being born small for gestational age (SGA) comprise the largest groups...

...), pulmonary vein stenosis (PVS), and neonatal diabetes caused by a novel mutation of the GATA6 gene in a small for gestational-age male neonate born at 32 weeks of gestation. Next-generation sequencing revealed the novel heterozygous variant c.1502C>G in the GATA6 gene, which determines the introduction...

.... 2023 Short stature Nutrition Vegetarian Vegan Growth Feeding difficulties Small for gestational age When a child with short stature and/or growth faltering, further abbreviated as growth failure (GF), is referred to a general practitioner or a paediatrician, the clinician...

...Régis Coutant; Bruno Leheup; Marc Nicolino; Jean-Pierre Salles Introduction: Growth hormone (GH) therapy improves height outcomes in short children born small for gestational age (SGA); however, real-world data on long-term GH exposure are few. Methods: We report results from an observational study...

...Ledjona Toni; Lukas Plachy; Petra Dusatkova; Shenali Anne Amaratunga; Lenka Elblova; Zdenek Sumnik; Stanislava Kolouskova; Marta Snajderova; Barbora Obermannova; Stepanka Pruhova; Jan Lebl Introduction: Among children born small for gestational age, 10–15% fail to catch up and remain short (SGA-SS...

...Elodie Adler; Anne-Sophie Lambert; Claire Bouvattier; Cécile Thomas-Teinturier; Anya Rothenbuhler; Paul de Boissieu; Agnès Linglart Introduction: About 8% of children born small for gestational age (SGA) do not reach a final height within the normal range. Recombinant human growth hormone (rhGH...

...Henrikki Nordman; Jarmo Jääskeläinen; Raimo Voutilainen The association between birth size and cardiometabolic disease risk may be U-shaped. Being born small for gestational age (SGA) has a definitive association with later cardiovascular risk, but the impact of being born large for gestational age...

.... Results: As of November 2017, 6,009 patients from 298 centers across 14 countries were enrolled in PATRO Children. Overall, 57.7% of patients had growth hormone deficiency (GHD), 25.8% were born small for gestational age (SGA), and 4.8% had Turner syndrome (TS). In total, 84.1% were rhGH treatment naïve...

...Judith S. Renes; Jaap van Doorn; Anita C.S. Hokken-Koelega Background: The reason for the insufficient catch-up growth seen in 10% of children born small for gestational age (SGA) is poorly understood. Disturbances in the growth hormone (GH) – insulin-like growth factor (IGF) axis might underlie...

... early patterns of infancy anthropometry and metabolic hormonal profile differ in preterm infants born small for gestational age (SGA) or appropriate for gestational age (AGA) from birth to 36 months of corrected age (CA). Methods: We recruited 110 very-low-birth-weight (VLBW) preterm infants (AGA = 60...

...Linda Lindström; Anna-Karin Wikström; Eva Bergman; Maria Lundgren Aim: To assess the relationship between severity of small for gestational age (SGA) and the risk of poor school performance, and to investigate whether adult stature modifies this risk. Methods: 1,088,980 Swedish children born...

... analyzed data at growth hormone (GH) start in prepubertal children diagnosed with idiopathic GH deficiency (IGHD), congenital GHD, acquired GHD, idiopathic short stature (ISS), and born small for gestational age (SGA) enrolled (1987-2012) in the Pfizer International Growth Study (KIGS®) from Europe, USA...

...Sinian Pan; Min Zhang; Yinya Li Aims: Hyperinsulinemic hypoglycemia (HH) is common in small-for-gestational-age (SGA) neonates. Diazoxide is often used as the first-line medication for HH in SGA neonates. Unfortunately, diazoxide is not authorized in China. We examined the effectiveness...

... small for gestational age with persistent short stature. Segregation analysis was performed, and genes in CNVs were compared with information from GWAS, gene expression in rodents' growth plates, and published information. Results: CNVs were detected in 13 cases. In 5 children a known cause of short...

...: After uncomplicated pregnancies, placentas (n = 48) were collected at term delivery of singleton infants who were appropriate for gestational age (AGA) or small for gestational age (SGA) (n = 24 in each subgroup). Placental mtDNA content was assessed by real-time PCR, placental SOD activity...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone Small for gestational age Appropriate for gestational age Very low birth weight Body composition...

...Anne-Marie Kappelgaard; Fumiaki Kiyomi; Reiko Horikawa; Susumu Yokoya; Toshiaki Tanaka Background/Aims: An examination of the effects of up to 260 weeks of growth hormone (GH) therapy on metabolic parameters in Japanese children born small for gestational age (SGA). Methods: Data were analysed from...

...J.S. Renes; J. van Doorn; P.E. Breukhoven; A.J. Lem; M.A.J. de Ridder; A.C.S. Hokken-Koelega Aims: To determine acid-labile subunit (ALS) levels in short small for gestational age (SGA) children and to assess the relationship between ALS levels and several clinical and laboratory characteristics...

... for metabolic health later on. Very low birth weight Small for gestational age Appropriate for gestational age Body composition Energy expenditure In this cohort of 67 VLBW children, median gestational age was 32 weeks (IQR 3 weeks), median birth weight was 1,350 g (IQR 550), median length 39...

... [ 4 ]. In clinical trials on doubling the dose in puberty in adolescents with GHD or non-GHD children (idiopathic short stature (ISS) or born small for gestational age (SGA)), a dose-dependent AH SDS gain was observed [ 14,17 ], but on both regimens AH was close to TH. AH is not only dependent...