..., regulates GnRH neurons, crucial for puberty onset and fertility. This study evaluates early puberty in primary adrenal insufficiency (PAI) patients due to MC2R gene alterations. Methods: Seven patients with PAI (P1-P7) from five unrelated families, all presenting with early or precocious puberty, were...

...Friederike Wagner; Robert Zeidler; Uta Ceglarek; Wieland Kiess; Jürgen Kratzsch; Alexander Gaudl; Ronald Biemann; Mandy Vogel Introduction: While the influence of various factors on classical androgen synthesis in children and adolescents and its impact on puberty has been widely investigated...

... of precocious puberty. Over the last decade, several new formulations have been approved. Methods: The Drugs and Therapeutics Subcommittee of the Pediatric Endocrine Society (PES) undertook a review to ascertain the current treatment options, prescribing behaviors, and practices of GnRHas among pediatric...

...-/undertreatment and allows the assessment of day profiles, especially in phases of changing (e.g., puberty) steroid requirements. We present here observational data from a larger cohort with longitudinal multiple measurements of s17-OHP. The values do not allow a significant differentiation between normal...

..., instructions or products referred to in the content or advertisements. 2023 Growth hormone therapy Puberty Children Idiopathic short stature Meta-analysis Growth hormone (GH) promotes statural growth and plays an integral role in metabolism 1 . It improves linear growth via hepatic...

... was maintained after adjusting for confounders. Conclusions: Higher IGF-1 levels in mid-childhood are associated with earlier puberty onset. The role of IGF-1 in the onset of puberty requires further investigation. Yearly clinical anthropometric evaluation was performed until year 2009. Thereafter, at age 6.7...

... adrenarche and remain higher throughout adulthood than in early childhood. The patterns of circulating 11-oxyandrogens throughout normal puberty have not yet been described. Methods: We conducted a secondary analysis of healthy youth participants, both males and females, enrolled in six prior endocrine...

... are optimal for normal growth, puberty, and bone health. The basis of using glucocorticoids and mineralocorticoids in the treatment of CAH remains, and in some individuals, it may be beneficial to add therapies to reduce the androgen load during certain life stages. [email protected] 19 11...

... of gonadotropin response to gonadotropin-releasing hormone analogs (GnRHas) corresponding to the activation of the hypothalamic-pituitary-gonadal axis that could differentiate central precocious puberty (CPP) from premature thelarche (PT) and using the electrochemiluminescence assay method. Methods: A total of 49...

..., and safety during long-term GH treatment to NAH for both ET and EUT groups. Results: The ET group was taller than the EUT group at all time points from preschool to maturity and was significantly taller at the onset of puberty ( p = 0.016), however, the difference was not significant at NAH. For the full...

... isomers changes during normal puberty, but there are no data in relation to vascular function. We aimed to evaluate vascular function, adiponectin, and its isomers longitudinally in peri-pubertal youth with obesity and controls. Methods: The study is a cohort longitudinal study involving 30 children...

... of the supplementation dose in adults. A specific note by a single respondent on the application of testosterone gel in adults was made: “We start with 10 mg gel, which we increase by 10 mg every 4 weeks if there are no side effects, usually the final dose is 40–50 mg.” To induce puberty in adolescents with PWS...

...Shlomit Shalitin; Galia Gat-Yablonski Background: The prevalence of obesity in childhood has increased dramatically in recent decades with increased risk of developing cardiometabolic and other comorbidities. Childhood adiposity may also influence processes of growth and puberty. Summary: Growth...

...Lea Oelkers; Mandy Vogel; Agnes Kalenda; Hans Christian Surup; Antje Körner; Jürgen Kratzsch; Wieland Kiess Introduction: Current health literature suggests that there has been a decline in the age of pubertal onset and that pubertal onset/duration of puberty may, besides weight status...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Noonan syndrome Growth hormone therapy Effectiveness Safety Near-adult height RASopathy Puberty Real-world evidence Adolescent Ras/mitogen-activated protein kinase...

... with a subsequent increase in TB BMAD by the age of 18 years. This supports the inference that testosterone levels in early puberty may influence subsequent bone mineral accrual. [email protected] 11 03 2019 9 08 2019 10 9 2019 © 2019 S. Karger AG, Basel 2019 Copyright / Drug...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Turner syndrome Puberty 17β-estradiol Oral induction Transdermal induction Cardinal features of Turner syndrome (TS) include short stature and primary ovarian insufficiency...

... recessive disorder. 46,XY-affected patients often remain undiagnosed until late puberty. Only 2 pediatric cases have been reported. Data on pubertal development in affected males are scarce. Aim: To report the clinical phenotype and hormonal studies of an aromatase-deficient boy during the prepubertal...

...-onset obesity on the cross talk between metabolic state, testes, and skeleton at late puberty. Methods: A cohort of adolescent and young adult males with severe childhood-onset obesity ( n = 21, mean age 18.5 years) and an age-matched control group were assessed for testicular hormones and X-ray...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Systemic juvenile idiopathic arthritis Short stature Growth hormone Puberty Biologicals targeting...