... treated with antithyroid drugs (ATDs) for many years. Thus the majority of pediatric patients with GD will need thyroidectomy or treatment with radioactive iodine (RAI; 131 I). Results: When ATDs are used in children, only methimazole should be used. Propylthiouracil is associated with an unacceptable...

...Ping-Ching Fong; Kin-Kee Pun; Yau-Ting Tai; Christina Wang; Rosie T.T. Yeung Severe adverse reactions to propylthiouracil occur in 1–5% of patients. Three major side effects, namely agranulocytosis, hepatotoxicity and drug-induced hypersensitivity, have been described though these syndromes...

...Angelica C. Vitug; Joel M. Goldman We review the cases of hepatic injury from propylthiouracil, methimazole and carbimazole in the English language literature and compare them to cases of agranulocytosis in a recent review. The data on hepatotoxicity confirm the findings for agranulocytosis...