...) developed central precocious puberty (CPP), which was influenced by a CA >4 years at diagnosis. The difference between AH-SDS and TH-SDS was not significant ( p = 0.3). The factors independently associated with AH below TH were CA >4 years at diagnosis, time between clinical manifestation...

... of precocious puberty. Over the last decade, several new formulations have been approved. Methods: The Drugs and Therapeutics Subcommittee of the Pediatric Endocrine Society (PES) undertook a review to ascertain the current treatment options, prescribing behaviors, and practices of GnRHas among pediatric...

... were strikingly similar to those encountered in MAS. To our knowledge, our patient is the youngest ever reported to present with precocious puberty due to a Sertoli cell tumor in the setting of PJS. [email protected] 28 12 2023 13 04 2024 16 04 2024 © 2024 The Author(s...

...Priyanka Bakhtiani; Rachana Srivastava; Mitchell E. Geffner Introduction: The onset of puberty is typically delayed in children with chronic kidney disease (CKD), with only three reported cases of precocious puberty in boys with CKD. Case Presentation: We report the case of a boy with end-stage...

... for a number of complications, such as peripheral precocious puberty and growth hormone excess, and monitored for hyperprolactinaemia. Due to fibroblast growth factor 23-mediated phosphate wasting, the patient was commenced on oral phosphate supplements and alfacalcidol. After 2 years of treatment...

..., instructions or products referred to in the content or advertisements. 2022 IGF-1 Puberty Precocious puberty Pubertal onset is a complex biological process that is affected by genetic, hormonal, nutritional, environmental, and socioeconomic factors. These interactions culminate in an increase...

... precocious puberty (CPP). Puberty resumes after treatment discontinuation, but little is known concerning fertility in women who have been treated with GnRHa for CPP during childhood. Methods: The PREFER (PREcocious puberty, FERtility) study prospectively analysed fertility, via a series of questionnaires...

..., concisely addresses topics related to changes in GnRHa usage in children and adolescents over the last decade. Topics related to the use of GnRHa in precocious puberty include diagnostic criteria, globally available formulations, considerations of benefit of treatment, monitoring of therapy, adverse events...

...Stella A. Nagel; Michaela F. Hartmann; Felix G. Riepe; Stefan A. Wudy; Martin Wabitsch Background/Aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported...

...Kristina M. Derrick; William A. Gomes; Robert C. Gensure Background/Aims: Patients with short stature (SS)/growth hormone deficiency (GHD) and precocious puberty (PP) undergo brain MRI to evaluate for structural brain abnormalities or pituitary lesions, and pituitary microadenomas are a common...

...Chiara Guzzetti; Carla Bizzarri; Elisa Pisaneschi; Mafalda Mucciolo; Emanuele Bellacchio; Anastasia Ibba; Letizia Casula; Antonio Novelli; Sandro Loche; Marco Cappa Background: The development of gonadotropin-independent (peripheral) precocious puberty in male children with primary adrenal...

...Paul B. Kaplowitz; Philippe F. Backeljauw; David B. Allen The use of gonadotropin-releasing hormone analogs (GnRHa) for the treatment of central precocious puberty (CPP), especially in girls, has increased rapidly in recent years. In the context of a secular trend towards earlier puberty onset...

...Delphine Zenaty; Joelle Blumberg; Nilani Liyanage; Evelyne Jacqz-Aigrain; Najiba Lahlou; Jean-Claude Carel; on behalf of co-investigators Background/Aims: To evaluate the efficacy and safety of a triptorelin pamoate (11.25 mg) 3-month formulation in the management of central precocious puberty (CPP...

... in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed in 43 CPP girls. Serum luteinizing hormone...

..., and autonomous hyperfunction of various endocrine organs. MAS frequently presents in females as precocious puberty (PP). Although many treatments have been proposed, the preservation of final height (FH) in these patients remains a challenge. Objectives: To evaluate the efficacy of tamoxifen in improving the FH...

... precocious puberty, diencephalic syndrome, GH deficiency and GH hypersecretion has been described in NF1 children. These conditions are commonly complications of optic pathway gliomas (OPG) involving the hypothalamic and sellar region. Nevertheless, these endocrine disorders have been observed also...

.... Conclusion: We present a case of testicular embryonal carcinoma in a boy who had presented 5 years before with features suggestive of gonadotrophin-independent precocious puberty. Testicular tumours are very rare in children and account for 4% of all cancers diagnosed in patients <18 years of age [ 12...

...Rita Santos-Silva; Artur Bonito-Vítor; Miguel Campos; Manuel Fontoura Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose...

...Kaspar Sørensen; Annette Mouritsen; Lise Aksglaede; Casper P. Hagen; Signe Sloth Mogensen; Anders Juul The decline in age at puberty in the general population has been paralleled by an increase in the number of girls referred for evaluation of precocious puberty (PP). In 1999, The Lawson Wilkins...

... to be characteristic in girls with idiopathic precocious puberty (IPP). The aim of this study was to examine the growth pattern of girls with early puberty compared to girls with IPP. Methods: We studied the growth pattern, from birth to presentation, of 61 girls with early puberty, of 40 girls with IPP and of 100...