...; 95% CI: 1.29–4.91) were significant predictors of PHD. Conclusions: The clinical predictors of PHD included blindness, pituitary gland abnormalities, and maternal substance abuse. These predictors help clinical decision-making related to the need for and frequency of hormone testing in pediatric...

... 133 subjects with an intact pituitary gland, 66% ( n = 87) had hypopituitarism, including 12 with DI. There were 4 patients in whom the bright spot of the neurohypophysis was not visualized despite a visible infundibulum: 3 had hypopituitarism, including 1 with DI. Table 3 describes...

...Allison J. Pollock; Tasa S. Seibert; Cristiana Salvatori; Patrizio Caturegli; David B. Allen Background/Aims: Autoimmune hypophysitis (AH) is a rare inflammatory disease of the pituitary gland causing varying degrees of hypopituitarism and/or sellar compression. Cranial MRI remains the best...

...-arginine test. Other pituitary hormone deficits are diagnosed based on serum levels of the concerning hormones. The size of the pituitary gland was measured on MRI images. Results: In PWS adults, IGF-I levels were low and IGFBP-3 levels normal when compared to healthy controls. GHD was diagnosed in 8–38...

... to in the content or advertisements. Microadenoma Oncogene-induced cellular senescence Pituitary gland Tumour progression Pituitary microadenomas, which have a diameter of less than 1 cm, are exceedingly common: autopsy and pituitary imaging indicate a prevalence of 10–25% in the adult population...

...R. Pfäffle; C. Kim; B. Otten; J.-M. Wit; U. Eiholzer; G. Heimann; J. Parks Pit-1 is a transcription factor which is expressed in the somatotrope, lactotrope, and thyrotrope cell population of the anterior pituitary gland from early fetal development throughout life. Mutations in the Pit-1 gene...

... of the pituitary gland. Of these patients, 8 had complete growth hormone (GH) deficiency, as evaluated by arginine infusion and L -Dopa-propranolol testing and nocturnal blood sampling, and 3 had GH neurosecretory dysfunction. Five patients had combined or multiple hormonal deficiencies. A statistically...