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Keywords: Pathogenesis
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Journal Articles
Subject Area:
Endocrinology
Hormone Research (1997) 47 (4-6): 227–234.
Published Online: 09 December 2008
... in paradoxical responses or nonresponsiveness to regulatory neurohormones. These abnormalities can be explained by defects at the intracellular transduction mechanism level. Knowledge of these defective pathways has made progress in the understanding of the pathogenesis of pituitary adenomas possible...
Journal Articles
Hormone Research (2007) 68 (Suppl. 5): 24–27.
Published Online: 10 December 2007
... to arise. The Ras-MAP kinase pathway is best known for its role in the pathogenesis of cancer. Somatic mutations in the genes encoding proteins involved in this pathway and the resulting gain of function are frequently found in cancers, and somatic mutations in PTPN11 are known to cause leukaemia...
Journal Articles
Hormone Research (2002) 57 (Suppl. 2): 31–34.
Published Online: 17 November 2004
..., they cause precocious puberty and/or characteristic gelastic seizures. Thus far, the pathogenesis of these alterations remains unknown. By examining two HHs associated with sexual precocity, we found that they contained astroglial cells expressing TGFα, but no LHRH neurons. In a third patient with HH, only...