... of the PRKAR1A gene. The patient was begun on treatment with metyrapone which was well tolerated over a 2-year period. The clinical picture has slightly improved, cortisoluria returned and remains within normal limits, but ACTH suppression persists. Conclusion: This is the first report on the clinical...

... PRKAR1A gene The Carney complex (CNC; MIM 160980) was first described in 1985 by J. Aidan Carney and coworkers [ 1 ] at the Mayo Clinic as the complex of myxomas, spotty pigmentation, and endocrine overactivity. The identification of this rare syndrome came from the study of 4 patients...

... gene Protein kinase A PRKAR1A gene Cowden disease PTEN gene Pigmented spots in the skin and the mucosa that are called lentigines (from the Latin lentigo , ‘small lentil’) are the hallmark of the familial lentiginosis syndromes. These disorders [presented in table  1...