...T.C.J. Sas; E.J. Gault; M. Zeger Bardsley; L.A. Menke; K. Freriks; R.J. Perry; B.J. Otten; S.M.P.F. de Muinck Keizer-Schrama; H. Timmers; J.M. Wit; J.L. Ross; M.D.C. Donaldson There has been no consensus regarding the efficacy and safety of oxandrolone (Ox) in addition to growth hormone (GH...

...Leonie A. Menke; Theo C.J. Sas; Theo Stijnen; Gladys R.J. Zandwijken; Sabine M.P.F. de Muinck Keizer-Schrama; Barto J. Otten; Jan M. Wit Background: The weak androgen oxandrolone (Ox) may increase height but may also affect glucose metabolism in girls with Turner syndrome (TS). Methods...

... of letrozole with that of oxandrolone on predicted adult height (PAH), puberty, bone mineral density, serum insulin-like growth factor 1 (IGF-1) and blood lipoproteins. Methods: In a prospective, double-blind, randomized, placebo-controlled clinical trial, 91 CDGP boys (12.6–14.6 years old) with predicted...

... 1998;49(suppl 2):62–66. 28. Stahnke N, Keller E, Landy H: Favorable final height outcome in girls with Ullrich-Turner syndrome treated with low-dose growth hormone together with oxandrolone despite starting treatment after 10 years of age. J Pediatr Endocrinol Metab 2002;15:129–138. 29. Nilsson KO...

...Andrei S. Chagin; Johanna Vannesjö; Lars Sävendahl Background: Systemic administration of the nonaromatizable androgen oxandrolone stimulates growth in girls with Turner syndrome and boys with a constitutional delay of growth and puberty. It is unknown if oxandrolone acts locally at the growth...

... cm.These results must be interpreted cautiously since the mean age of starting treatment was relatively late at 9.1-13.1 years. However, the overall modesty and interpatient variability of response to GH in Turner syndrome, and continuing uncertainty as to the role of oxandrolone and the timing of estrogen...

... with the anabolic steroid oxandrolone (Oxa) on height velocity and on Turner-specific bone age (BA’TS) and, second, to estimate the gain in final height taking the age at the onset of treatment into account. The mean advancement of BA’TS in 2 years of treatment was 2.5 years/2 years in group 1 (low dose GH: 16 IU/m...

... = 47), 2.6 IU/m 2 body surface area daily or combination treatment (n = 44) with the same dose of rhGH and oxandrolone 0.1 mg/kg body weight orally, for the first 12 months of this study. During the 1 st year of therapy, there was a striking increase in height velocity (HV) in both groups, from 4.0...

... will review how girls with delayed puberty of different etiologies can benefit from the following therapeutic alternatives: follow-up without hormonal therapy; administration of growth hormone, anabolic steroids (e.g. oxandrolone) or estrogens and progestogens, and psychological support. 2 12 2008...

...Jean-Claude Job; Fabienne Landier 22 girls with Turner syndrome aged 10.8 ± 2.4 years with bone age 8.58 ± 1.32 years, randomized in two groups, were treated for 3 years with either growth hormone (GH), 0.1 U/kg daily (group A), or GH, 0.1 U/kg, plus oxandrolone, 0.06 mg/kg (group B). This resulted...

... Androgens Oestrogens Conjugated oestrogens Ethinyloestradiol Gonadotropins Aromatase inhibitors Oxandrolone Puberty is defined as the transition between infancy and adulthood, when important physical, functional, psychological and psychosocial changes take place. During this period...

...Meir Lampit; Ze’ev Hochberg Background/Aims: Two modalities of androgen therapy prevail in the treatment of constitutional delay of growth (CDG): monthly injections of testosterone or daily tablets of the non-aromatizable oxandrolone. The present study was undertaken to prospectively compare both...

...E.E. Joss; R.P. Zurbrügg; O. Tönz; P.-E. Mullis In 18 girls with Turner syndrome, glucose tolerance was studied before treatment and after 6 and 24 months of growth-promoting treatment with recombinant human growth hormone (24 IU/m 2 /week; 8 mg/m 2 /week) and oxandrolone (0.06 mg/kg/day), as well...

...B. Doeker; J. Müller-Michaels; W. Andler We report on a 9-year-old boy with early puberty who had been treated with oxandrolone because of constitutional delay of growth. Treatment was started at the age of 6.25 years. During the treatment with oxandrolone over 22 months, the height velocity...