...Maria Keller; Mandy Vogel; Antje Garten; Stina Ingrid Alice Svensson; Elena Rossi; Peter Kovacs; Yvonne Böttcher; Wieland Kiess Background: Childhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life. The correlation of epigenetic...

... loss over time in adolescents undergoing MBS and identify preoperative predictors of weight loss. Methods: This was a prospective, observational cohort study of 73 adolescents (12–19 years) living with obesity undergoing MBS. Absolute and relative changes in anthropometric and biochemical parameters...

... measurements: one during the pandemic and one post-pandemic. Results: Obesity rates increased from 12.8% pre-pandemic to 15.4% during the pandemic, slightly decreasing to 15.0% post-pandemic. BMI-standard deviation scores (SDSs) increased during the pandemic, in both sexes, across all ages and all...

...Michal Nevo Shenker; Shlomit Shalitin Background: Despite all the technological advances in treatment of patients with type 1 diabetes (T1D), glucose control remains suboptimal in most patients. In addition, a relatively high percentage of patients with T1D, including children, have obesity...

...: Cushing’s syndrome (CS) constitutes one of the most challenging diagnostic assessments for paediatric endocrinologists. The clinical presentation of some children with exogenous obesity overlaps with those observed in hypercortisolism states. Accurate, non-invasive first-line tests are necessary to avoid...

..., there appear to be gaps and contradictory findings regarding the association of overweight and obesity with the synthesis of adrenal-derived 11-oxygenated androgen (11-OA) serum levels. With this study, we aimed to examine how overweight and obesity affect 11-OA serum levels during puberty in a large cohort...

...Mimi S. Kim; Trevor A. Pickering; Devyn L. Cotter; Nicole R. Fraga; Shan Luo; Cindy Y. Won; Mitchell E. Geffner; Megan M. Herting Introduction: Patients with classical congenital adrenal hyperplasia (CAH) exhibit an increased prevalence of obesity from childhood including central adiposity...

...Annalisa Deodati; Giorgia Bottaro; Daniela Germani; Fabrizia Carli; Sabrina Tait; Luca Busani; Veronica Della Latta; Anna Paola Pala; Francesca Maranghi; Roberta Tassinari; Amalia Gastaldelli; Cinzia La Rocca; Stefano Cianfarani; LIFE PERSUADED Project Group Introduction: Obesity is a worldwide...

... cases/million/year). Although non-malignant, craniopharyngioma causes major endocrine and visual morbidities including hypothalamic obesity, yet mechanisms leading to obesity are poorly understood. This study investigated the feasibility and acceptability of eating behaviour measures in patients...

... present with hypothalamo-pituitary dysfunction. Suprasellar tuberculoma is rare in children and adults. Novel Insights Suprasellar tuberculoma can present with hypothalamic obesity. Hypothalamic obesity in suprasellar tuberculoma can be reversed after long-term antituberculosis treatment...

.... The differences in 11KT trajectories in males and females are small compared to changes in testosterone for males and estradiol for females during puberty. Obesity appears to influence the trajectories of 11-oxyandrogens during puberty. [email protected] 15 03 2022 4 10 2022...

...Robert H. Lustig; Ilene Fennoy Perhaps the most unexpected development in pediatric endocrinology in the past 50 years has been the recognition of obesity as an endocrine/metabolic disorder rather than a life choice or moral failing. The history of obesity research is disjointed, having followed...

...Cosimo Giannini; Nella Polidori; Costanza Renata Neri; Ebe D’Adamo; Francesco Chiarelli; Angelika Mohn Introduction: Metabolic Syndrome (MetS) represents a common dysmetabolic state in children with obesity. Although data in youth show a role of gut hormones (GH) in the risk of developing MetS...

... included in the study. Mean age was 123.1 (±82.2) months old. 50.3% of patients were hospitalized, and 12.1% of patients were admitted to intensive care. Preexisting diagnoses of diabetes mellitus, obesity, and hypothyroidism were associated with an increased risk of hospital and ICU admission, independent...

...Annika Janson; Kajsa Järvholm; Lovisa Sjögren; Jovanna Dahlgren; Andrew J. Beamish; Eva Gronowitz; Torsten Olbers Severe obesity in adolescence profoundly impacts health and social well-being. Lifestyle modifications are seldom successful in maintaining sufficient weight loss to mitigate the risk...

...Nella Polidori; Francesca Mainieri; Francesco Chiarelli; Angelika Mohn; Cosimo Giannini Background: Type 2 diabetes (T2D) represents just the tip of the iceberg of the complex metabolic alterations associated with obesity and other clinical conditions associated to impaired adipose tissue storage...

...Mojca Jensterle; Andrej Janež Background: Obesity treatment based on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) proved to limit morbidity and mortality in adult population. In children, optimizing lifestyle intervention (LSI) and reducing culpable environmental exposures represent...

...Eleni Z. Giannopoulou; Stefanie Zorn; Melanie Schirmer; Gloria Herrmann; Sabine Heger; Thomas Reinehr; Christian Denzer; Hannah Rabenstein; Morten Hillmer; Nadine Sowada; Reiner Siebert; Julia von Schnurbein; Martin Wabitsch Introduction: Genetic obesity is rare and quite challenging...

...Simona Filomena Madeo; Ilaria Stanghellini; Barbara Predieri; Silvia Ciancia; Francesco Leo; Patrizia Bruzzi; Olga Calabrese; Lorenzo Iughetti Background/Aims: Obesity is a multifactorial disease caused by the interaction of genetic, environmental, and behavioral factors. Currently, only a small...

...Alexia Sophie Peña; Jennifer Harrington; Sarah Kate Peters Black; Roger Gent; Craig Hirte; Jennifer J. Couper; Esko Wiltshire Introduction: Youth with obesity have abnormal vascular function that relates to the anti-atherogenic adipose-derived hormone, adiponectin. The distribution of adiponectin...