...Ozgur Duman; Erdem Durmaz; Sema Akcurin; Mustafa Serteser; Senay Haspolat Melatonin, a major photoperiod-dependent hormone, regulates circadian rhythms and biological rhythms and acts as a prominent sleep promoter. Symptoms related to hypermelatoninemia have been reported in individuals...

...Katharina Diethelm; Lars Libuda; Katja Bolzenius; Barbara Griefahn; Anette E. Buyken; Thomas Remer Background/Aims: The study objective was to assess longitudinal associations between melatonin secretion and reported sleep duration from childhood to early adulthood. Methods: In the frame...

...J.C. Commentz; H. Uhlig; A. Henke; H.H. Hellwege; R.P. Willig To delineate the development of melatonin (MLT) production during childhood, we measured the excretion of MLT and 6-hydroxymelatonin sulfate (MLTS) in the urine of children (n = 134) from the 26th week of gestation until the age of 20...

...J.C. Commentz; K. Helmke Hypothalamic hamartomata are benign malformations of the brain consisting of heterotopic nervous tissue, and are often associated with precocious puberty and gelastic seizures in early childhood. We report for the first time the melatonin plasma values of a girl...

...Yuji Okatani; Masataka Okada; Yusuke Sagara To clarify the role the opioid system plays in mediating the stimulation of prolactin release by melatonin, we performed two separate studies between the 6th and 8th days of the follicular phase in normal young women. In the first study, serum prolactin...

... of these alterations. Other overt rhythms which have been shown to be of lower amplitude and/or phase-advanced are those of body temperature and of the peripheral levels of hormones such as cortisol, melatonin, TSH, testosterone, prolactin and GH. Mean hormonal levels are generally decreased, but overall cortisol...

.... Differences in acrophases, mesors and amplitudes could be demonstrated. For instance the acrophase may be phase-advanced in the elderly for plasma cortisol, DHEA-S, 18-OHDOC, the amplitude may be modified for testosterone, 18-OHDOC, proteins, melatonin, gonadotrophins. The administration as a function of time...

...Yuji Okatani; Yusuke Sagara The purpose of this study was to evaluate the role of the opioid system and the estrogen environment in the nocturnal secretion of melatonin in women with secondary amenorrhea (SA). Nocturnal melatonin concentrations in patients with SA were significantly higher than...

...G.M. Brown Depression, mania and probably starvation all induce changes in pineal function. At present it is unknown what secondary effects on the endocrine and other systems are produced by these changes. Studies in rats have established an entraining effect of melatonin on locomotor activity...

...Anita Cavallo; Gail E. Richards; Edward R. Smith We examined the relation between nocturnal melatonin and hormonal markers of puberty in 57 normal children and adolescents and 39 subjects with disorders of pubertal onset. Melatonin was measured in hourly blood samples drawn overnight by constant...

...A. Cavallo A concurrent effect of age and puberty has hampered assessment of the influence of melatonin on human puberty. This study examined the pineal-puberty interaction in 41 subjects (ages 5–17 years) whose puberty was asynchronous from age (constitutional delay, hypopituitarism and idiopathic...

...A. Cavallo; G.E. Richards; Walter J. Meyer; Ron D. Waldrop We tested the hypothesis that acute 5-hydroxytryptophan (5-HTP) administration would cause an increase in concentrations of plasma melatonin to levels observed during the spontaneous nocturnal melatonin surge. We administered 5-HTP orally...

...S.F. Pang; P.L. Tang Serum and pineal concentrations of melatonin and N-acetylserotonin in 4-month-old (adult) and 15-month-old (senile) male hamsters were studied. The animals were adapted under 12:12 h light:dark cycle for a minimum of 1 month before they were decapitated at mid-light and mid...

...G.A. Bubenik Using highly specific antibodies, melatonin was identified in the gastrointestinal tract of the rat as early as several hours of postnatal life. Its amount progressively increased and reached the adult levels around day 21. Exogenously administered melatonin concentrates in all parts...

... of pineal serotonin-N-acetyltransferase activity and melatonin content. These results suggest a role for prostaglandins in the regulation of pineal function. Indomethacin Prostaglandins Pineal gland Melatonin Monoamine oxidase activity Catechol-O-methyl transferase activity 10 12 1979 8...

...Maria I. Vacas; Daniel P. Cardinali High-affinity binding of melatonin to crude membrane preparations of bovine pineal gland was examined by a rapid filtration procedure through Whatman GFB paper. Maximal melatonin binding was attained in 60 min at 37 °C, in 2 h at 25 °C and in 5 h at 0 °C; at 25...

...David E. Blask; Christopher A. Leadem; Bruce A. Richardson Afternoon but not morning injections of melatonin (Mel) resulted in significant 68, 50 and 20% reductions in seminal vesicle, ventral prostate and testicular weights, respectively, as compared with underfed controls. As in the animals...

...-releasing hormone stimulated TSH secretion, but significantly decreased the cold-induced TSH response both at noon and at midnight. Neither hypothalamic thyrotropin-releasing hormone concentrations nor serum thyroid hormone levels were affected by pinealectomy. Melatonin injected intravenously (1 and 10 mg...

...Kevin Rudeen Daily subcutaneous injections of various dosages of melatonin were given early in the light phase to groups of adult male golden hamsters maintained in a long photoperiodic cycle (14 h light). This injection was followed by a second daily injection of melatonin late in the light phase...

...C.H. Tan; J.C.M. Khoo Melatonin was extracted from human sera, ventricular and lumbar cerebrospinal fluids taken within an hour from 25 patients undergoing neurosurgical operations such as ventricular shunts and craniotomy. Using a radioimmunoassay procedure, it was possible to measure...