... individuals, e.g., the very select group of healthy centenarians, the remodeling process is successful. The reasons why centenarians are able to reach the extreme limits of human life span are still largely unknown; however, several studies in humans have shown that longevity is associated with a significant...

...J.A.M.J.L. Janssen; S.W.J. Lamberts Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Adrenopause DHEA-S DHEA DDSP Longevity Somatopause Andropause Menopause Fig. 1 Age-related changes to the endocrine system. BMD = Bone mineral density. Fig. 1. Age...