...Michael B. Ranke; Anders Lindberg; on behalf of the KIGS International Board Many children with idiopathic short stature (ISS) remain short as adults. Height can be improved permanently by growth hormone (GH) treatment, as in children with Turner syndrome or born small for gestational age. Although...

... and resistance can be difficult. Subcategorization based on distance to target height and onset of puberty is arbitrary, but useful. Growth Short stature Growth hormone Pathophysiology KIGS One would not expect there to be remaining uncertainty about the definition of idiopathic short stature (ISS...

... and growth response and (3) serum IGF-I response and growth response after 1 year of GH treatment among patients in the Pfizer International Growth Study database (KIGS). KIGS patients were eligible for the study if they were classified as having idiopathic GH deficiency, acquired GH deficiency, Turner...

... in the Pfizer International Growth Study Database (KIGS). Results: We identified 147 short children with thalassemia who were treated with rhGH in KIGS. Of these, approximately 40% had a primary diagnosis of GH deficiency (GHD). They had low birth weight, short parents, reduced genetic height potential, low...

..., instructions or products referred to in the content or advertisements. KIGS Normal distribution Polygenic inheritance Genetic determinant Adolescent growth spurt MirhueI A. P recce Institute of Child Health, University of London, UK Idiopathic Short Stature Horm Res 19%:45(suppl 2):56-58...

... method is still very limited. At the present time, the TW2 is still the method of choice. It is hoped that the development of a computerized method of assessment will lead to greater accuracy in the determination of skeletal maturity. KIGS Bone age Greulich and Pyle Tanner-Whitehouse FELS ©...

... to in the content or advertisements. KIGS Idiopathic short stature Familial short stature Constitutional delay Constitutional delay in growth and puberty Predicted adult height Idiopathic Short Stature Horm Res I996:45(suppl 2):59-63 David A. Price Department of Child Health. Manchester University...

... of the changes in the nutritional, hygienic and health status of a population. The secular trend in adult height has slowed down since the second world war, but is still continuing in most industrialized countries. 9 12 2008 KIGS Secular change Growth Age at menarche Peak height velocity ©...

... that are currently available will not be entirely suitable for routine use. 9 12 2008 Michael B. Ranke Department of Paediatrics. Eberhard-Karls-Universität. Tubingen. Germany Growth Standards Horm Res I996;45(suppl 2):35-4l Disease-Specific Standards in Congenital Syndromes Key Words KIGS Growth standards...

... definitions of bone maturation. This is becoming feasible with the advent of expert systems for the automatic recognition of different stages of bone maturation. KIGS Skeletal maturity Bone age Height prediction Final height TW2 method © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage...

..., or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. KIGS...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. KIGS Growth standards Percentiles Height...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. KIGS Bone dysplasias Auxology Genetics Growth Standards Horm Res...

...; however, they can all be addressed as a way of improving the usefulness of growth standards in a wide variety of situations. KIGS Growth standards Conditional centiles Growth chart © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

.... Data from 57,968 children in the KIGS (Pfizer International Growth Study database) were analyzed to determine the effects of recombinant human GH (Genotropin®) on these side effects. The diagnostic groups were idiopathic GH deficiency (IGHD) (n = 27,690), congenital GHD (CGHD) (n = 2,547...

... function. Of the 1,135 patients in KIGS with Prader-Willi syndrome, GH secretion was tested in 424 (37%). While 26% of those tested had normal GH levels, nearly three quarters of the patients had low GH levels. IGF-I levels are also low in nearly all children with Prader-Willi syndrome. These data...

..., as their implementation is not only practical but also inexpensive. The Pfizer International Growth Database (KIGS) analysis of IGF-I (n = 2,750) and IGFBP-3 (n = 1,300) levels in children with idiopathic GHD shows that these two parameters are now firmly embedded in diagnostic strategies around the world. © 2004 S...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. KIGS KIMS Growth hormone Growth hormone deficiency Clinical decision making Clinical database The widespread use of growth hormone (GH) therapy in children with growth...

... for a longer ‘pre-pubertal’ growth phase. We reviewed the KIGS (Pharmacia International Growth Database) data of patients with IGHD who had been treated with gonadotropin-releasing hormone agonists (GnRHa) in order to see if a greater gain in height could be achieved by altering the tempo of pubertal...

...Michael B. Ranke; Anders Lindberg; o on behalf of the KIGS International Board Growth hormone (GH) deficiency is normally diagnosed when the affected child is between 6 and 8 years of age and a lack of normal growth first becomes noticeable. Some patients, however, are diagnosed as being GH...