...) is an unexplained phenomenon described in some pathological (sellar, suprasellar, and hypothalamic disorders) and overgrowth syndromes. It has been suggested that the paradoxical growth is due to other GH variants, GH-like moieties, prolactin, insulin, insulin-like growth factors (IGFs), and unidentified serum...

...Elena Inzaghi; Barbara Baldini Ferroli; Danilo Fintini; Armando Grossi; Valerio Nobili; Stefano Cianfarani Background/Aims: Insulin-like growth factor (IGF)-I is related to cardiometabolic risk in adults, whereas the metabolic role of IGF-II is unclear. The aim of this study was to assess IGFs...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Idiopathic short stature IGF-binding proteins Growth retardation Insulin-like growth factors Growth hormone (GH...

.../POU1F1 and GLI2 have been shown to cause pituitary hormone deficiency. In addition, heterozygous mutations or gene deletions in the growth hormone-insulin-like growth factor (GH-IGF) axis such as the GH, GH-releasing hormone receptor, GH receptor, STAT5b, IGF-I, IGF-I receptor and the acid labile subunit...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Somatropin Relative bioavailability Transgenic cow Pharmacodynamics Insulin-like growth factors Human growth hormone...

... examines the role of hormones in feto-placental growth with particular emphasis on insulin, the insulin-like growth factors and glucocorticoids. 4 05 2009 26 06 2009 19 10 2009 © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth Growth hormone Insulin-like growth factors Responsiveness Inter-individual variability in responsiveness to growth hormone (GH) has been apparent since...

...J. Argente; N. Caballo; V. Barriosa; M.T. Muñoz; J. Pozo; J.A. Chowen; M. Hernández Numerous endocrine abnormalities of the growth hormone (GH)-insulin-like growth factor axis have been described in patients with both anorexia nervosa and obesity during childhood and adolescence. These alterations...

... = 15), and group 4 (Tanner stage V, n = 24). Steroid levels and insulin-like growth factors were determined to characterize clinical pubertal development. MBG was similar in all groups but MSI increased at stage II and retained similar values throughout puberty, with those of group I being...

...Paivi J. Tapanainen; Peter Bang; Hermann L. Muller; Kristin Wilson; Ron G. Rosenfeld Pregnancy is associated with important changes in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein (IGFBP) axis, but the importance of these growth factors for fetal growth...

... of insulin-like growth factor (IGF) physiology. Such investigations have demonstrated that expression of both IGF-I and IGF-II is essential to normal in utero growth of the fetus, while IGF-II is required for normal placental growth. IGF-I is necessary for normal in utero maturation and postnatal growth...

... cells. Of the various osteogenic growth factors identified in bone, there is sufficient evidence to document an important role for the insulin-like growth factor (IGF) system in mediating this coupling process. Studies on the basic aspects of the IGF system reveal that it is complex and involves...

...P. Monget; N. Besnard; C. Huet; C. Pisselet; D. Monniaux In the ovary, insulin-like growth factors (IGFs) enhance both proliferation and differentiation of follicular cells by potentiating gonadotropin’s actions. The biological effects of IGFs are strikingly modulated by IGF-binding proteins...

...C. Lalou; C. Lassarre; M. Binoux Limited proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) is a normal process in the regulation of insulin-like growth factor (IGF) activity, which we have reproduced in vitro using plasmin and recombinant human non-glycosylated IGFBP-3 in order...

...Victor K.M. Han Insulin-like growth factors (IGF-1 and IGF-2) are synthesized by many tissues in response to GH treatment and regulate cellular growth and differentiation. Fetal serum contains abundant GH, and many fetal tissues express GH receptors, but the clinical significance of GH in fetal...

...Robert C. Baxter The actions and bioavailability of the insulin-like growth factors (IGFs) are regulated by a family of six IGF binding proteins. IGFBP-3, the major circulating IGFBP, is unique in combining with a glycoprotein, the acid-labile subunit (ALS), to form a ternary complex with IGF-I...

... IU/kg/week) and on a high dose (0.5 IU/kg/week), the following results were obtained. Insulin-like growth factor-I (IGF-1) in serum: basal, 68.6 ± 37 ng/ml; low dose, 176.9 ± 65 ng/ml (p ≤ 0.05); high dose, 380.6 ± 200 ng/ml (p < 0.01). IGF-binding protein-3 in serum: basal, 2.13 ± 0.58 mg/l; low...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ovary Insulin-like growth factors Follicle Horm Res 1994:42:44-48...

...José F. Cara Increasing evidence indicates that the ovary contains an insulin-like growth factor (IGF) system complete with ligands, binding proteins, and receptors. Through their interaction with IGF receptors on theca-interstitial cell surface membranes, the ligands, IGF-I and IGF-II, synergize...

...W. Kiess; Y. Yang; U. Kessler; A. Hoeflich Insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin. It is now thought that IGF-II acts as a growth factor during fetal life and development. In rats, IGF-II levels...