...Jan M. Wit; Sjoerd D. Joustra; Monique Losekoot; Hermine A. van Duyvenvoorde; Christiaan de Bruin The current differential diagnosis for a short child with low insulin-like growth factor I (IGF-I) and a normal growth hormone (GH) peak in a GH stimulation test (GHST), after exclusion of acquired...

...-3, alone and in combination. b Different models, including ALS. The calculated values for area under the ROC curve are given in brackets. ROC, receiver operating characteristic; AUC, area under the curve; IGF-I, insulin-like growth factor I; IGFBP-3, IGF-binding protein-3; ALS, acid-labile subunit...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Insulin-like growth factor I Insulin-like growth factor binding protein 3 Growth hormone deficiency Diagnosis Predictive value of tests Bayesian approach...

...Maarten A.C. Broeren; Johannes G. Krabbe; Lianne S. Boesten; Anita C.S. Hokken-Koelega; Yolanda B. de Rijke Background: The analysis of insulin-like growth factor I (IGF-I) is an important tool for pediatricians in the diagnosis and treatment of growth hormone deficiency in children. However...

... with genetically proven Kabuki syndrome (8 boys and 10 girls; ages 3.3-9.9 years, with a mean of 6.7 years) who underwent growth hormone (GH) stimulation tests were evaluated in a prospective study. Two GH stimulation tests were conducted, including insulin-like growth factor I (IGF-I) and IGF-binding protein 3...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cognition IQ Insulin-like growth factor I...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone deficiency Growth hormone therapy Insulin-like growth factor I Compliance Adherence The objectives of growth hormone (GH) treatment are to correct...

..., the Gothenburg models and the Cologne model. With these models, 50-80% of the variance could be explained. When used prospectively, individualized dosing reduces the variation in growth response in comparison with a fixed dose per body weight. Insulin-like growth factor-I-based dose titration also led...

...: The patient, a 12-year-old boy from consanguineous parents, was referred for short stature at the age of 7 years (height: -5.4 SD score). He had low serum insulin-like growth factor I (IGF-I) and IGF binding protein 3 and a blunted IGF-I response to recombinant human GH; molecular analysis of the GH receptor...

...J.A.M.J.L. Janssen Background: Insulin-like growth factor I (IGF-I) immunoassays are primarily used to estimate IGF-I status. Recently an IGF-I-specific kinase receptor activation assay (KIRA) was developed as an alternative method for measuring IGF-I bioactivity. When compared with IGF-I...

... were performed at the endocrine laboratory of the VU University Medical Center with commercially available, regularly internal and external quality controlled immunoassays. Prader-Willi syndrome Growth hormone Insulin-like growth factor I Endocrine function Magnetic resonance imaging...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fetal alcohol syndrome Pregnancy Alcohol abuse Insulin-like growth factor I Insulin-like growth factor II...

... considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. The measurement of insulin-like growth factor I (IGF-I), due to its close GH dependency, was proposed for diagnosing GHD. However, a number of factors may affect the measurements. Herein, we propose...

... hormonal evaluation revealed elevated insulin-like growth factor I (IGF-I) levels (938 ng/ml, nv 40–190), prolactin (PRL) (98.0 ng/ml, nv 1.7–24.0) and mean growth hormone (GH) nocturnal concentration (147 ng/ml). Basal adrenal, gonadal and thyroid functions were normal. Hand-wrist bone age was 3.6 years...

... of hypothalamo-pituitary dysfunction and those with a history of cranial irradiation, tumour treatment, traumatic brain injury or subarachnoid haemorrhage. Conclusions: Subjects with ≥3 pituitary hormone deficiencies plus a low insulin-like growth factor I level do not need provocative testing. For those who...

...Giovanni Federico; Tania Favilli; Luisa Cinquanta; Claudio Ughi; Giuseppe Saggese Failure to thrive is common in children with celiac disease. As alterations in the growth hormone-insulin-like growth factor I (GH-IGF-I) growth axis have been reported in these patients, we studied the behavior...

...V. Barrios; J. Argente; J. Pozo; F. Hervás; M.T. Muñoz; J.I. Sánchez; M. Hernández The normal values of insulin-like growth factor I (IGF-I), IGF-binding proteins 1 and 3 (IGFBP-1 and IGFBP-3), and the high-affinity growth hormone binding protein (GHBP) are not well established in large series...

... metabolism Leucine metabolism Growth hormone Glucocorticosteroids Insulin-like growth factor I Nitrogen balance Catabolic illnesses Horm one R e se a rch Se ssio n 2: GH, IGF-I and M etabolism Horm Res 1996:46:202-207 Morey W. Haymond Nelly Mauras Nemours Children s Clinic Jacksonville. Fla.. USA...

...G. Radetti; C. Paganini; F. Ántoniazzi; B. Pasquino; R. Valentini; L. Gentili; L. Tato Growth hormone binding proteins, insulin-like growth factor I and insulinlike growth factor binding proteins were determined in 54 children and adolescents affected by type 1 diabetes mellitus (25 prepubertal...

... production and intermediary metabolism. In this article, we review the literature and, from this and our own work, propose a new hypothesis which links the hypersecretion of growth hormone to reduced hepatic secretion of insulin-like growth-factor I (IGF-I) as a direct result of reduced portal insulin levels...