...W.L. Clarke; L. Gonder-Frederick; D.J. Cox The literature contains numerous reports of the frequency of severe hypoglycaemia in childhood insulin-dependent diabetes mellitus. Unfortunately, most of these data have been collected in such a manner as to make comparisons between them difficult. Most...

...J. Dupre; I. Hramiak; J.L. Mahon; C.R. Stiller Ciclosporin-induced noninsulin-receiving remissions in insulin-dependent diabetes mellitus are associated with enhancement of beta-cell function. Patients in remission show virtually no insulin responses to parenteral glucose, contrasting...

...J. Leclère; G. Weryha Auto-immunity may occur in all endocrine tissues, with a particular prevalence in thyroid and pancreatic islets. The most demonstrative clinical expressions of this auto-immunity are Graves’ disease and insulin dependent diabetes. In the former, extensive data are available...

.... Autonomic neuropathy Adolescents Insulin-dependent diabetes Cardiovascular testing Pupillometry Ewing and Clarke pioneered interest in ‘beside’ testing of autonomic nerve function by describing five cardiovascular reflex tests: heart rate variation during deep breathing (DBHRV), valsalva ratio...