..., instructions or products referred to in the content or advertisements. 2024 Diabetes autoimmunity Diabetes prevention Insulin secretion B-cell replacement C-peptide Type 1 diabetes is a multifactorial heterogenous disease with a progressive pancreatic beta-cell loss and a requirement...

.... Conclusion: This is the first report of annual longitudinal glycaemic profiles in a patient with 6q24-related TNDM during remission. We identified fluctuations in β-cell function and insulin resistance during remission. Transient neonatal diabetes mellitus Glycaemic profile Insulin secretion Insulin...

... function relative to IR would be the major determinant of the persisting IGT status and the development of overt T2D [ 8 ], along with further weight gain and no improvement of insulin sensitivity [ 9 ]. Defects in insulin secretion and action can be diagnosed even in obese adolescents with NGT, i.e...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Congenital hyperinsulinism ATP-dependent potassium channel Insulin secretion Congenital hyperinsulinism (CHI...

... in children born small for gestational age (SGA). We explored insulin and glucose metabolism in SGA children treated with a fixed GH dose over 1 year. Methods: In the North European Small for Gestational Age Study (NESGAS), 110 short SGA children received GH at 67 µg/kg/day for 1 year. Insulin secretion...

... with a seizure. All affecteds responded well to diazoxide. Affecteds failed to adequately suppress insulin secretion following oral glucose tolerance test or prolonged fasting; none had protein-sensitive hypoglycemia. Linkage analysis mapped the HI locus to Chr10q21-22, a region containing 48 genes. Three novel...

... sensitivity Insulin secretion Short stature Small for gestational age • Different mutations in the insulin-like growth factor-I (IGF-I) receptor (IGF1R) gene have been associated with impaired prenatal and postnatal growth. • The IGF-I/IGF1R system is implicated in the regulation of glucose...

...N. Potau; L. Ibañez; S. Riqué; A. Carrascosa Using a simple and standardized method we estimated both insulin secretion and insulin sensitivity in peripheral tissues in relation to Tanner pubertal stages. Early insulin response, mean blood glucose (MBG), mean serum insulin (MSI), glucose uptake...

... the possible mechanisms (impaired insulin secretion and action, role of the environmental factors) which may lead to the impairment in glucose handling associated with ageing. We also point out that not all aged subjects are glucose intolerant; in fact, it has been suggested that only those aged subjects who...

... with diabetic glucose tolerance was significantly increased at the second evaluation and insulin secretion was markedly reduced in these patients. Deterioration of glucose tolerance and/or of insulin secretion over time was never accompanied by a significant worsening of clinical and/or nutritional status...

... inhibitory effect on insulin secretion. Hypoglycemia produced by IGF-I infusions (free-fall study and glucose clamps) had a different effect on counterregulatory responses compared with insulin. The glucagon response was absent, growth hormone (GH) release was attenuated, while norepinephrine levels were...

...A.J. Scheen; P.J. Lefebvre Besides insulin secretion, insulin sensitivity plays a key role in the feedback glucose-insulin closed loop. It can be altered in numerous physiological, pathological and pharmacological conditions. It can be estimated in vivo using methods that open the feedback loop...

...S. Caprio; D. Boulware; V. Tamborlane Insulin and glucose clamp techniques were used to investigate insulin action and insulin secretion during childhood. Preliminary results suggest that growth hormone (GH) therapy leads to changes in glucose, amino acid and insulin responses...

... secretion was not significantly affected over time with 2 IU, whereas 3 and 4 IU produced significant increases which persisted after 2 years. Results indicate that glucose homeostasis is maintained under GH therapy at the expense of a compensatory increase in insulin secretion which persists at higher GH...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Insulin secretion Glucagon secretion Adrenergic regulation Liver glycogen Horm Res 1991:36:80-85 © 1991 S. Karger A G . Basel 0301 -0163/91 /0362-0080Î 2.75/0 Central...

... glucose and D -glyceraldehyde increased insulin secretion. These stimuli and the amino acids leucine and alanine also provoked insulin release in freshly isolated tumor cells. Under these conditions, glucose utilization had a K m of 4.6 m M and maximal velocity of 0.9 nmol/min/10 6 cells. A continuous...

...I.C. Green; C. Southern; K. Ray Human growth-hormone-releasing hormone [(1-44)NH 2 ] (hGHRH) was a potent stimulus for insulin release from rat islets of Langerhans in vitro; the optimum concentration used was 10 -11 M. The dose response curves for hGHRH effects on insulin secretion were notably...

...A. Faure; M. Haouari; B.C.J. Sutter Long-term oestradiol treatments induce hyperinsulinism and low glycaemia. Time-related experiments were performed to determine when this effect appears in islets from treated rats. Oestradiol first inhibited the insulin secretion for 2 days and later stimulated...

... galanin could affect these responses. Thus, in the mouse, galanin and pancreastatin both inhibit basal and stimulated insulin secretion, and stimulate basal glucagon secretion. Galanin is thereby more potent than pancreastatin. The study also showed that galanin potently inhibits insulin secretion...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Glucagon secretion Insulin secretion Dorsal pancreas Ventral pancreas Rat Glucose Carbamylcholine Arginine Glucagon...