..., and automated insulin delivery remains complex due to the disease’s heterogeneity. Summary: This review explores the advancements and challenges in beta-cell replacement therapies, including pancreas and islet cell transplantation, stem cell-derived β-cell generation, and biotechnological innovations. Pancreas...

...Alaina P. Vidmar; Choo Phei Wee; Sarah-Jeanne Salvy; Jomanah Abduljalil Bakhsh; Michael I. Goran Introduction: To date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept study...

...: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and most severe cause of persistent hypoglycemia in infants and children. In the 65 years since HI in children was first described, there has been a dramatic advancement in the diagnostic tools available...

.... In adolescents and adults, hyperinsulinemic hypoglycemia is most frequently caused by an insulin-producing tumor. Case Presentation: A 17-year-old, previously healthy male presented with recurrent and severe episodes of hypoglycemia. Diagnostic evaluation was consistent with hyperinsulinemic hypoglycemia...

... hemoglobin A Adolescent Insulin NIH Rising rates of obesity have fueled increases in the incidence of prediabetes and type 2 diabetes (T2D) in the pediatric population [ 1‒3 ]. Although youth-onset T2D is increasing in incidence [ 4 ], the overall prevalence remains low, affecting...

...Paul S. Thornton; Charles A. Stanley; Diva D. De Leon Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly. It was the development of the insulin...

... were able to extract and purify “isletin” to treat human diabetes in 1921. Rapid scientific progress over the next 100 years led to an understanding of insulin synthesis, structure and function, production of modified synthetic insulins, and the physiopathology that permitted classification of diabetes...

... two separate paths in the 20th century, based on two independent yet overlapping paradigms. Proponents of the “Energy Storage” hypothesis point to data implicating monogenetic disorders, the ventromedial hypothalamus, insulin, cortisol, and the adipocyte itself in the pathogenesis of obesity...

..., instructions or products referred to in the content or advertisements. Hyperinsulinism Beta cells Hypoglycemia Ammonia Insulin 29 06 2022 20 07 2022 11 8 2022 [email protected] National Institutes of Health (NIH) 10.13039/100000002 Activating...

..., instructions or products referred to in the content or advertisements. Obesity Growth Puberty Leptin Adiponectin Insulin Obesity during childhood and adolescence remains one of the most important issues in global health. Over the past 4 decades, obesity in children of all ages has increased...

... the WHO African region. To better understand actual access to medicines by patients, we focused on diabetes and surveyed pediatric endocrinologists from 5 countries and assessed availability and true cost for insulin and glucagon. Results: Most medicines that are essential in pediatric endocrinology...

... born to obese mothers (SKOT-II) with infants born mainly to nonobese mothers (SKOT-I). Methods: Infants from SKOT-I ( n = 273) and SKOT-II ( n = 132) were examined including anthropometric measurements and blood samples analyzed for glucose, insulin, insulin-like growth factor-I (IGF-I), adiponectin...

.... It is unclear whether a subtle growth failure still persists despite the optimization of therapy. Our aim was to analyse pubertal growth, adult height, and metabolic profile in a cohort of children with T1DM undergoing intensive insulin treatment by multiple daily injections or continuous subcutaneous insulin...

..., and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. Method: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens...

...Federico Baronio; Laura Mazzanti; Ylenia Girtler; Federica Tamburrino; Anisia Fazzi; Fiorenzo Lupi; Silvia Longhi; Giorgio Radetti Background: Growth hormone (GH) influences glucose homeostasis by negatively affecting insulin sensitivity, leading to a compensatory increase in insulin secretion...

... response to a meal with an exaggerated insulin surge and subsequent hypoglycemia. We evaluated the role of GLP-1 in the pathogenesis of PPH by examining the effects of GLP-1 receptor blockade on glucose and insulin response to a meal. Methods: Six children with known PPH after surgery underwent a mixed...

... in vitro observations on pancreatic tissue isolated from patients with HH, where diazoxide caused an unanticipated increase in insulin secretion. These observations have important implications for managing patients with HH. 26 03 2013 7 06 2013 25 7 2013 © 2013 S. Karger AG, Basel...

...Monique van de Lagemaat; Joost Rotteveel; Annemieke C. Heijboer; Harrie N. Lafeber; Mirjam M. van Weissenbruch Background/Aims: Since insulin-like growth factor type I (IGF-I) and insulin regulate growth in term infants, they were studied in relation to nutrient intake and growth until 6 months...

... heterogenic response to somatostatin analogues are confirmed [ 29,30 ]. Congenital hyperinsulinism Lanreotide Beta cell Treatment Insulin Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemic episodes in infancy [ 1 ]. Focal and diffuse CHI forms have been...

...Mandana Moosavi; Jade Séguin; Quan Li; Constantin Polychronakos Objective: To analyze the correlation between insulin requirements of type 1 diabetic (T1D) patients and genotype at type 2 diabetes (T2D) risk loci, obtained in our genome-wide association study. Methods: From a database of detailed...