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1-20 of 135
Keywords: Insulin
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Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr 1–15.
Published Online: 30 October 2024
..., and automated insulin delivery remains complex due to the disease’s heterogeneity. Summary: This review explores the advancements and challenges in beta-cell replacement therapies, including pancreas and islet cell transplantation, stem cell-derived β-cell generation, and biotechnological innovations. Pancreas...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr 1–11.
Published Online: 11 June 2024
...Alaina P. Vidmar; Choo Phei Wee; Sarah-Jeanne Salvy; Jomanah Abduljalil Bakhsh; Michael I. Goran Introduction: To date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept study...
Journal Articles
Diva D. De Leon, Jean Baptiste Arnoux, Indraneel Banerjee, Ignacio Bergada, Tricia Bhatti, Louise S. Conwell, Junfen Fu, Sarah E. Flanagan, David Gillis, Thomas Meissner, Klaus Mohnike, Tai L.S. Pasquini, Pratik Shah, Charles A. Stanley, Adrian Vella, Tohru Yorifuji, Paul S. Thornton
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2024) 97 (3): 279–298.
Published Online: 14 July 2023
...: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and most severe cause of persistent hypoglycemia in infants and children. In the 65 years since HI in children was first described, there has been a dramatic advancement in the diagnostic tools available...
Journal Articles
Dana Reynolds, Lauren M Mitteer, Winifred Sigal, Linda Boyajian, Heather McKnight, Tricia Bhatti, Lisa States, Susan Becker, N. Scott Adzick, Katherine Lord, Diva D. De Leon
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2024) 97 (2): 187–194.
Published Online: 14 July 2023
.... In adolescents and adults, hyperinsulinemic hypoglycemia is most frequently caused by an insulin-producing tumor. Case Presentation: A 17-year-old, previously healthy male presented with recurrent and severe episodes of hypoglycemia. Diagnostic evaluation was consistent with hyperinsulinemic hypoglycemia...
Journal Articles
Subject Area:
Karger e-Journal Backfile Collection 2023
,
Endocrinology
,
Women's and Children's Health
Mary Ellen Vajravelu, Emily Hirschfeld, Acham Gebremariam, Charles F. Burant, William H. Herman, Karen E. Peterson, Jennifer L. Meijer, Joyce M. Lee
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2023) 96 (3): 316–324.
Published Online: 13 June 2023
... hemoglobin A Adolescent Insulin NIH Rising rates of obesity have fueled increases in the incidence of prediabetes and type 2 diabetes (T2D) in the pediatric population [ 1‒3 ]. Although youth-onset T2D is increasing in incidence [ 4 ], the overall prevalence remains low, affecting...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2022) 95 (6): 631–637.
Published Online: 29 November 2022
...Paul S. Thornton; Charles A. Stanley; Diva D. De Leon Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly. It was the development of the insulin...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2022) 95 (6): 593–607.
Published Online: 29 November 2022
... were able to extract and purify “isletin” to treat human diabetes in 1921. Rapid scientific progress over the next 100 years led to an understanding of insulin synthesis, structure and function, production of modified synthetic insulins, and the physiopathology that permitted classification of diabetes...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2022) 95 (6): 638–648.
Published Online: 29 November 2022
... two separate paths in the 20th century, based on two independent yet overlapping paradigms. Proponents of the “Energy Storage” hypothesis point to data implicating monogenetic disorders, the ventromedial hypothalamus, insulin, cortisol, and the adipocyte itself in the pathogenesis of obesity...
Journal Articles
Kara E. Boodhansingh, Elizabeth Rosenfeld, Katherine Lord, N. Scott Adzick, Tricia Bhatti, Arupa Ganguly, Diva D. De Leon, Charles A. Stanley
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2022) 95 (5): 492–498.
Published Online: 11 August 2022
..., instructions or products referred to in the content or advertisements. Hyperinsulinism Beta cells Hypoglycemia Ammonia Insulin 29 06 2022 20 07 2022 11 8 2022 [email protected] National Institutes of Health (NIH) 10.13039/100000002 Activating...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2022) 95 (2): 120–136.
Published Online: 15 June 2021
..., instructions or products referred to in the content or advertisements. Obesity Growth Puberty Leptin Adiponectin Insulin Obesity during childhood and adolescence remains one of the most important issues in global health. Over the past 4 decades, obesity in children of all ages has increased...
Journal Articles
Amanda Rowlands, Emmanuel Ameyaw, Florent Rutagarama, Joel Dipesalema, Edna Siima Majaliwa, Joyce Mbogo, Graham D. Ogle, Jean-Pierre Chanoine
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2018) 90 (2): 82–92.
Published Online: 26 July 2018
... the WHO African region. To better understand actual access to medicines by patients, we focused on diabetes and surveyed pediatric endocrinologists from 5 countries and assessed availability and true cost for insulin and glucagon. Results: Most medicines that are essential in pediatric endocrinology...
Journal Articles
Anni Larnkjær, Ken K. Ong, Emma M. Carlsen, Katrine T. Ejlerskov, Christian Mølgaard, Kim F. Michaelsen
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2018) 90 (1): 28–38.
Published Online: 29 June 2018
... born to obese mothers (SKOT-II) with infants born mainly to nonobese mothers (SKOT-I). Methods: Infants from SKOT-I ( n = 273) and SKOT-II ( n = 132) were examined including anthropometric measurements and blood samples analyzed for glucose, insulin, insulin-like growth factor-I (IGF-I), adiponectin...
Journal Articles
Carla Bizzarri, Tiziana Antonia Timpanaro, Maria Cristina Matteoli, Ippolita Patrizia Patera, Marco Cappa, Stefano Cianfarani
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2018) 89 (3): 172–177.
Published Online: 16 February 2018
.... It is unclear whether a subtle growth failure still persists despite the optimization of therapy. Our aim was to analyse pubertal growth, adult height, and metabolic profile in a cohort of children with T1DM undergoing intensive insulin treatment by multiple daily injections or continuous subcutaneous insulin...
Journal Articles
Cornelis J. de Groot, Adriaan van den Berg, Bart E.P.B. Ballieux, Herman M. Kroon, Edmond H.H.M. Rings, Jan M. Wit, Erica L.T. van den Akker
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2017) 87 (4): 254–263.
Published Online: 31 March 2017
..., and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. Method: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens...
Journal Articles
Federico Baronio, Laura Mazzanti, Ylenia Girtler, Federica Tamburrino, Anisia Fazzi, Fiorenzo Lupi, Silvia Longhi, Giorgio Radetti
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2016) 86 (3): 196–200.
Published Online: 06 September 2016
...Federico Baronio; Laura Mazzanti; Ylenia Girtler; Federica Tamburrino; Anisia Fazzi; Fiorenzo Lupi; Silvia Longhi; Giorgio Radetti Background: Growth hormone (GH) influences glucose homeostasis by negatively affecting insulin sensitivity, leading to a compensatory increase in insulin secretion...
Journal Articles
Subject Area:
Topic Article Package: Pharmacology 2016
,
Endocrinology
,
Women's and Children's Health
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2016) 85 (2): 140–146.
Published Online: 23 December 2015
... response to a meal with an exaggerated insulin surge and subsequent hypoglycemia. We evaluated the role of GLP-1 in the pathogenesis of PPH by examining the effects of GLP-1 receptor blockade on glucose and insulin response to a meal. Methods: Six children with known PPH after surgery underwent a mixed...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2013) 80 (2): 129–133.
Published Online: 25 July 2013
... in vitro observations on pancreatic tissue isolated from patients with HH, where diazoxide caused an unanticipated increase in insulin secretion. These observations have important implications for managing patients with HH. 26 03 2013 7 06 2013 25 7 2013 © 2013 S. Karger AG, Basel...
Journal Articles
Monique van de Lagemaat, Joost Rotteveel, Annemieke C. Heijboer, Harrie N. Lafeber, Mirjam M. van Weissenbruch
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2013) 80 (2): 92–99.
Published Online: 29 June 2013
...Monique van de Lagemaat; Joost Rotteveel; Annemieke C. Heijboer; Harrie N. Lafeber; Mirjam M. van Weissenbruch Background/Aims: Since insulin-like growth factor type I (IGF-I) and insulin regulate growth in term infants, they were studied in relation to nutrient intake and growth until 6 months...
Journal Articles
Peter Kühnen, Jan Marquard, Andrea Ernert, Thomas Meissner, Klemens Raile, Gertrud Wannenmacher, Oliver Blankenstein
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2012) 78 (2): 106–112.
Published Online: 14 August 2012
... heterogenic response to somatostatin analogues are confirmed [ 29,30 ]. Congenital hyperinsulinism Lanreotide Beta cell Treatment Insulin Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemic episodes in infancy [ 1 ]. Focal and diffuse CHI forms have been...
Journal Articles
Journal:
Hormone Research in Paediatrics
Horm Res Paediatr (2012) 77 (5): 305–308.
Published Online: 15 May 2012
...Mandana Moosavi; Jade Séguin; Quan Li; Constantin Polychronakos Objective: To analyze the correlation between insulin requirements of type 1 diabetic (T1D) patients and genotype at type 2 diabetes (T2D) risk loci, obtained in our genome-wide association study. Methods: From a database of detailed...
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