...Andrew Dauber; Moshe Phillip; Jean-Marc Ferran; Nicky Kelepouris; Navid Nedjatian; Anne Helene Olsen; Alexander Augusto de Lima Jorge Introduction: Children with idiopathic short stature (ISS) are known to have varying responses to growth hormone (GH) treatment (GHT). Methods: We conducted a post...

... studies in children with idiopathic short stature (ISS; 15 studies), small for gestational age ( n = 6 studies), chronic renal failure ( n = 3), Noonan syndrome ( n = 1), and growth hormone deficiency ( n = 1). Significant differences in the effects of rhGH on pubertal timing were found by clinical...

...Elena Inzaghi; Edward Reiter; Stefano Cianfarani Idiopathic short stature (ISS) comprises a wide range of conditions associated with short stature that elude the conventional diagnostic work-up and are often caused by still largely unknown genetic variants. In the last decade, the improvement...

...Christopher J. Child; Charmian A. Quigley; Gordon B. Cutler, Jr; Wayne V. Moore; Kupper A. Wintergerst; Judith L. Ross; Ron G. Rosenfeld; Werner F. Blum Background/Objectives: Growth hormone (GH) treatment of idiopathic short stature (ISS) received US Food and Drug Administration approval in 2003...

...Charmian A. Quigley; Ying Grace Li; Milton R. Brown; Sreekumar G. Pillai; Poulabi Banerjee; Robin S. Scott; Werner F. Blum; John S. Parks Background/Aims: The term idiopathic short stature (ISS) describes short stature of unknown, but likely polygenic, etiology. This study aimed to identify genetic...

... adolescent boys; however, the effects of this intervention on quality of life (QoL) are unknown. This study assesses whether GH, AI, or their combination impacts the QoL of adolescent males with idiopathic short stature (ISS) from both the adolescent and the parent perspective. Method: A randomized open...

...-centre, open-label study to assess the short-term efficacy and safety of this recombinant human growth hormone (r-hGH) preparation for prepubertal children with idiopathic short stature in South Korea. Methods: The SYNERGY study ( ClinicalTrials.gov NCT01746862) was conducted at 9 centres throughout...

...Anenisia C. Andrade; Youn Hee Jee; Ola Nilsson Idiopathic short stature is a common condition with a heterogeneous etiology. Advances in genetic methods, including genome sequencing techniques and bioinformatics approaches, have emerged as important tools to identify the genetic defects in families...

... analyzed data at growth hormone (GH) start in prepubertal children diagnosed with idiopathic GH deficiency (IGHD), congenital GHD, acquired GHD, idiopathic short stature (ISS), and born small for gestational age (SGA) enrolled (1987-2012) in the Pfizer International Growth Study (KIGS®) from Europe, USA...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Idiopathic short stature IGF-binding proteins Growth retardation Insulin-like growth factors Growth hormone (GH...

... children (age 3-11 years), 41 with GH deficiency (GHD) and 58 with idiopathic short stature (ISS), were randomized to a fixed dose (43 µg/kg/day) or a prediction model-guided individualized dose (17-100 µg/kg/day) and followed up for 24 months. In a longitudinal and mixed within- and between-subjects study...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Health-related quality of life Short stature Growth hormone deficiency Idiopathic short stature Patient and parent assessment Outcome research Assessment of health-related...

...-labile subunit (ALS)-deficient families, heterozygous carriers of IGFALS gene mutations are frequently shorter than their wild-type relatives, suggesting that IGFALS haploinsufficiency could result in short stature. We have characterized IGFALS gene variants in idiopathic short stature (ISS...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. SHOX gene Turner syndrome Idiopathic short stature Léri-Weill dyschondrosteosis Short stature...

...-deficient, idiopathic short stature (ISS). Objective: To demonstrate if an individualized, formula-based, target-driven GH regimen for children with ISS would lead to a height (Ht) gain to -1.3 SDS during the first 24 months of treatment of this 4-year study, with less variability than with standard weight...

... secretion. However, the challenge is how to optimize GH treatment with respect to growth, safety and cost [ 1 ]. Growth hormone deficiency Idiopathic short stature Small for gestational age Insulin-like growth factor I Growth hormone receptor © 2013 S. Karger AG, Basel 2013 Copyright...

... in Egyptian children with idiopathic short stature (ISS) and describe patients with IGFD. Methods: This cross-sectional study included 50 children with ISS following up at the Diabetes Endocrine and Metabolism Pediatric Unit at Cairo University Pediatric Hospital. Children were included based on the following...

... GH deficiency (IIGHD), mild IIGHD, dissociated GH release (DGHR) and normal GH release (NGHR) and anthropometric birth data as adequate for gestational age (AGA) or small for gestational age (SGA). GH release after stimuli classifies AGA patients as IIGHD or as idiopathic short stature (ISS). Aim...

... analysis of 199 short children born small for gestational age (SGA) or with normal birth size (idiopathic short stature, ISS). Methods: After selection with a modified scoring system for SHOX and a novel score for IGF1 and IGF1R defects, direct sequencing and multiplex ligation-dependent probe...

...Isabelle Durand-Zaleski In the context of health-care costs, containment and economic downturn, there is a question as to whether the high cost of growth hormone (GH) therapy for patients with idiopathic short stature (ISS) is worth the health benefit provided. The economic evaluations of GH...