...). His serum IGF-1 was low (16 ng/mL; reference range: 179–540). IGFBP-3 (1.3 mg/L; 3.1–9.5) and ALS (565 mU/mL; 1,500–3,500) were also low. GH stimulation test was normal, and GHBP was markedly elevated (6,300 pmol/L; 240–3,000). Additionally, the boy had insulin resistance and liver steatosis. His...

...Ingrid Baier; Ana Pereira; Pedro Ferrer; German Iñiguez; Verónica Mericq Introduction: Pubertal onset is triggered by multiple neuroendocrine interactions. The role of prepubertal IGF-1 in this process has not been explored in both sexes. Our objective was to analyze the association of prepubertal...

... being below the expected value for age and sex in both. The small positive effects of rhIGF-1 on fat mass during the second year could reflect the severe nature of their IGF-1 deficiency [ 7 ]. There was a concomitant increase in lean mass from 15,471.8 g at baseline to 19,490.5 and 22,165.6 g after 1...

... standard deviation scores (SDSs) were: IGF2 mut –1.75, upd(7)mat –1.69, nonsyndromic SGA –1.52, 11p15LOM –0.61, and clinical (tested negative) –0.55. The median IGF-2:IGF-1 concentration ratio was 2.57 in IGF2 mut compared to 5.44 in 11p15LOM ( p = 0.036), 7.84 in clinical, and 7.98 in upd(7)mat. Upd(7)mat...

...-3.3), and IGF-1 level <-2 standard deviation scores (SDS) following treatment cessation (OR 19.3, 95% CI 3.6-103.1). In the multivariate analysis, only IGF-1 level <-2 SDS (OR 13.3, 95% CI 2.3-77.3) and complete GHD (OR 6.3, 95% CI 1.2-32.8) were associated with the outcome. Conclusion: At final...

...) and in normal children, determining their impact on height and the IGF system. Patients and Methods: In 188 normal and 79 ISS children levels of IGF-1, IGFBP-3, ALS, ternary complex formation (TCF) and IGFALS gene sequence were determined. Results: In sum, 9 nonsynonymous or frameshift IGFALS variants (E35Gfs...

...Maria Ivone Oliveira Pinto Vilela; Marina de Oliveira Serravite; Natália Bragança Oliveira; Patrícia Carneiro de Brito; Antônio Ribeiro-Oliveira Jr.; Marcos Borato Viana Background: Endocrine complications after acute lymphoblastic leukemia (ALL) are common. Methods: Final height, GH/IGF-1 axis...

.... Growth hormone GH/IGF-1 axis Growth disorders IGF-1 Growth hormone receptor GH1 gene Genetics STAT5B Acid-labile subunit In approximately 80% of children who are referred to a pediatric clinic because of short stature, no definite cause can be established, even after a thorough...

... for gestational age (AGA) served as controls. Phosphorylation of JAK2/STAT5 and expression of GH receptor, suppressor of cytokine signaling 2 (SOCS-2) and cytokine-inducible SH2-containing protein (CIS) in the liver were determined by Western blotting. The expression of insulin-like growth factor 1 (IGF-1) mRNA...

... it is unknown whether these effects are due to direct effects of growth hormone on hematopoietic cells or if they are caused by the induction of insulin-like growth factor-1 (IGF-1) synthesis. We recently discovered that colony-stimulating factor-1 (CSF-1) and interleukin-3 (IL-3) induce expression...

...G. DeLuca; M. Maggiolini; M. Bria; M. Caracciolo; A. Giorno; M. Salerno; S. Marsico; M. Lanzino; C. Brancati; S. Andò The physiological role of GH secretion on growth retardation remains to be elucidated especially in patients with β-thalassemia. In the present study, we investigated IGF-1...

...G.R. Ambler; B.H. Breier; S.N. McCutcheon; P.D. Gluckman To further evaluate the role of growth hormone (GH) in the neonatal period, the effects of GH or insulin-like growth factor 1 (IGF-1) administration were studied in the neonatal GH-defïcient rat. Groups of pups from newborn litters were...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone IGF-1 Ovary Testis Spermatogenesis Ovulation IVF Assisted conception Anovulation Horm Res...

...Omar Ali; Melanie Shim; Eileen Fowler; Pinchas Cohen; William Oppenheim Background/Aims: Childhood cerebral palsy (CP) is associated with osteopenia and the GH-IGF axis plays an important role in bone metabolism. We studied the relationship between spinal bone mineral density (BMD) and serum IGF-1...

... with weight gain in ALL survivors [ 12, 26 ]. The aim of this study was to analyze some of the most important biochemical markers involved with obesity (leptin, insulin, and insulin-like growth factor 1 (IGF-1) blood levels) in a group of patients submitted to ALL treatment during childhood and who...

... the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS...

...A. Belgorosky; M.A. Rivarola In normal puberty, as well as in precocious puberty, serum GH, IGF-1 and IGFBP-3 are increased as a consequence of the increase in sex hormone secretion. However, the effect of suppressing sex hormones on serum GH and IGF-1 in precocious puberty is controversial...