.... This review focuses on the hypothesis that testicular germ cell cancer, which originates from germ cell neoplasia in situ, is of foetal origin and associated with other male reproductive problems through a testicular dysgenesis syndrome, also including foetal origin of impaired spermatogenesis, hypospadias...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Amenorrhea Disorders of sex development Hypospadias NR5A1 Steroidogenic factor 1 [ SF1/Ad4BP/NR5A1 (MIM...

... for male puberty, including facial and body hair growth and genital maturation [ 1 ]. Affected individuals are 46,XY males with ambiguous external genitalia. They usually present with perineoscrotal hypospadias as well as a clitoral-like phallus, severely bifid scrotum, unilateral cryptorchidy...

...Y. Aigrain; A. Cheikhelard; H. Lottmann; S. Lortat-Jacob The aim of this review is to summarize the various steps of the surgical procedures to treat a hypospadias. Hundreds of procedures have been described but most of them follow the same principles. They include correction of a ventral curvature...

...Magdalena Fossum; Agneta Nordenskjöld The surgical treatment of severe hypospadias can be very challenging. In selected cases with severe lack of tissue, cultured autologous urothelial cells can be used to create a transplanted neourethra. The algorithm for using tissue-engineering techniques...

...Tsutomu Ogata; Jocelyn Laporte; Maki Fukami MAMLD1 (mastermind-like domain containing 1), previously known as CXorf6 (chromosome X open reading frame 6), has been shown to be a causative gene for hypospadias. This is primarily based on the identification of nonsense mutations (E124X, Q197X...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Aarskog syndrome CHARGE association Dysmorphology Hypospadias Opitz syndrome Prader-Willi syndrome Robinow syndrome VATER association D...

...R.K. Linskens; R.J.H. Odink; J.C. van der Linden; S. Ekkelkamp; H.A. Delemarre-van de Waal This report discusses the clinical findings on two patients with 45, X/46, XY Mosaicism two boys presented with penile hypospadias and cryptorchidism. A dysgenetic ovary and a testis were found in one boy...

...Benchun Liu; Koray Agras; Emily Willingham; Marcelo L.B. Vilela; Laurence S. Baskin Background/Aims: Synthetic estrogens induce hypospadias, an anomaly of genital tubercle/urethral development. Activating transcription factor 3 (ATF3), which is estrogen-responsive in vitro, is upregulated...

... SGA has been well documented, whereas data on gonadal development are limited. Prospective studies, case-control investigations and registry surveys show that impaired intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately two...

...L. Garavelli; P. Cerruti-Mainardi; R. Virdis; S. Pedori; G. Pastore; M. Godi; S. Provera; A. Rauch; C. Zweier; M. Zollino; G. Banchini; N. Longo; D. Mowat; G. Neri; S. Bernasconi Hypospadias, when the urethra opens on the ventral side of the penis, is a common malformation seen in about 3 per 1,000...

...: Mutant SRD5A1 isoenzyme does not seem to play a crucial role in the development of hypospadias. 16 04 2003 19 11 2003 26 3 2004 © 2004 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... in the 6 patients. Dihydrotestosterone Dihydrotestosterone kinetics 5α-Reductase deficiency Micropenis Hypospadias In male sexual determination and differentiation, although testosterone is the androgen that differentiates the Wolffian duct, it acts only as a pre-hormone in other...

... individuals, 0.3–17 years of age, with a male phenotype and either hypospadias and/or cryptorchidism. Four patients, 0.3–15 years of age, had carcinoma in situ, 1 boy had Sertoli-cell-only pattern and the remainder prepubertal histology. Gonadoblastoma or invasive carcinoma was not found. On the basis of our...