... Turner Syndrome Working Group Introduction: Natural oestrogen administration as oral or transdermal 17β-estradiol is recommended for pubertal induction in girls with hypogonadism. However, suitable low-dose formulations are not consistently available globally. This questionnaire study aimed to identify...

.... 2021 Disorders of sex development Fallopian tubes Ovary Hypogonadism Persistent Müllerian duct syndrome Sertoli cell Testis Uterus Disorders of sex development (DSDs) result from anomalies in the sexual differentiation of the gonads and/or the genitalia, wherein...

... by intellectual disability, behavioural problems, hypothalamic dysfunction, and specific dysmorphisms. Hypothalamic dysfunction causes growth hormone deficiency, dysregulation of energy balance, and hypogonadism. Although hypogonadism is prevalent in PWS, there are no clear guidelines for diagnosis and treatment...

.... Disorder of sex development Hypogonadism Isolated 17, 20 lyase deficiency Isolated 17, 20 lyase deficiency is a rare cause of sex steroid deficiency, with 46 XY individuals displaying under-masculinization of varying severity at birth. Biochemical diagnosis requires proof of diminished 17, 20...

..., optimization of the metabolic profile, and psychosocial maturation and well-being. Summary: Testosterone therapy is a cornerstone of the management of hypogonadism in boys. Since the initial report of the chemical synthesis of testosterone, several formulations have continued to develop, and although many...

...Hanneke M. van Santen; Marry M. van den Heuvel-Eibrink; Marianne D. van de Wetering; W. Hamish Wallace Hypogonadism after treatment for childhood cancer is a recognized complication and its cause may be subdivided into primary gonadal failure and central hypogonadism. Here, we provide an overview...

... deviations (SD) shorter than the mean of an age-matched reference without hypospadias or epispadias [ 1,2 ]. Micropenis can result from various disorders including hypo- or hypergonadotropic hypogonadisms as well as androgen resistance including androgen insensitivity syndrome and 5 alpha-reductase...

...Kirsi Jahnukainen; Risto Heikkinen; Markus Henriksson; Sture Andersson; Kaisa K. Ivaska; Leena-Riitta Puukko-Viertomies; Outi Mäkitie Background: We evaluated the body composition and its association with hypogonadism in adult male long-term acute lymphoblastic leukemia (ALL) survivors. Methods...

... be associated with raised ESR, adverse quality of life measures and an abnormality of IGF-1 bioavailability. Adolescence Chronic disease Hypogonadism Growth Inflammation All data were expressed as medians (with ranges) and analysed using SPSS v19.0 (SPSS Inc., Chicago, Ill., USA). Statistical...

... stimulates pituitary gonadotropin secretion and then gonadal steroid secretion. Pubertal delay is defined as the presentation of clinical signs of puberty 2-2.5 SD later than in the normal population. Three major groups of etiopathogeneses are described: (1) hypogonadotropic hypogonadism, (2...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypogonadism Growth Inflammation Chronic disease In adolescents...

...Ian R. Reid Background: A number of disease states and drugs can upset the balance between bone formation and resorption resulting in increased fracture risk. Glucocorticoids are the most recognized cause of secondary osteoporosis. Hypogonadism, weight loss, and chronic inflammation are other...

...Marianna Rachmiel; Tzvy Bistritzer; Eli Hershkoviz; Auni Khahil; Orna Epstein; Ruth Parvari Background and Objective: Woodhouse-Sakati syndrome (WSS) is a rare autosomal-recessive disorder characterized by a combination of hypogonadism, alopecia, diabetes mellitus (DM), mental retardation...

...Silvano Bertelloni; Giampiero I. Baroncelli; Piernicola Garofalo; Stefano Cianfarani Androgen treatment represents a main aspect of clinical management of boys with hypogonadism from adolescence onwards. Androgen replacement therapy is required to induce secondary sexual characteristics and adult...

... on the regulation and action of hormones involved in the control of growth and puberty [ 1,3 ]. The hypogonadism that is encountered in these patients may encompass a range of abnormalities of the hypothalamic/pituitary/gonadal/end-organ axis, including hypogonadotropic hypogonadism [ 4 ], abnormality of sex...

... action, which is necessary for ovulation. Although inactivating mutations in LHB and LHCGR are rare in comparison to other genetic and non-genetic causes of hypogonadism, they should be considered in the differential diagnosis of oligo-amenorrhea and infertility. In genetic males, severe homozygous...

... mass is not fully known, but a crucial role is played by the sex steroids. Patients with central precocious puberty show an increased bone mineral density (BMD) for their chronological age, but appropriate for their bone age and pubertal stage. In girls and boys with hypogonadism, as well...

... hormone and follicle-stimulating hormone levels at 5.8 and 2.8 U/l, respectively. The hypogonadotropic hypogonadism was due to an elevated prolactin level of 8.8 nmol/l. She also had a low potassium level of 3.2 mmol/l, and a high urinary aldosterone level of 158 nmol/day. The hyperprolactinemia...

...C. Dacou-Voutetakis; M. Drakopoulou Two brothers were examined because of ichthyosis and hypogonadism. Their testes were small. There was no response of plasma testosterone to human chorionic gonadotropin and no response of plasma luteinizing hormone and follicle-stimulating hormone to intravenous...

...Nancy L. Niles; Scott J. McCorkell; Nicholas J.Y. Woodhouse Six male patients (aged 21-34 years) with isolated hypothalamic hypogonadism were given subcutaneous pulses of gonadotrophin-releasing hormone every 90 min for 14-74 weeks. The therapy produced an increase in testicular volume (4 patients...