... with loss-of-function pathogenic variants in KCNQ1 is characterized by postprandial hyperinsulinemic hypoglycemia. Case Presentation: Clinical data for the proband were extracted from the medical records. The proband presented with fasting hypoglycemia due to hyperinsulinism in early childhood as well...

...Maïté Verkest; Karl Logghe; Marlies Van Loocke Introduction: In this article, the importance of holistic care is highlighted trough the case of a 10-year-old female with diabetes type 1 presenting with recurrent severe hypoglycemia. Case Presentation: A 10-year-old female, with type 1 diabetes...

... Gesù from 1985 to 2022. Results: Hypoglycemia occurred within the first year of life in 85.5% of patients, median time to diagnosis was 1 day (IQR 14 days). Ninety-two percent of patients were treated with diazoxide: 66.9% were responsive. Octreotide was administered to 28.6% of patients: 61.4% were...

...Joseph I. Wolfsdorf; Terry G.J. Derks; Danielle Drachmann; Pratik Shah; Paul S. Thornton; David A. Weinstein Sick children often have a decreased appetite and experience vomiting and diarrhea; however, hypoglycemia (plasma glucose concentration ≤50 mg/dL or 2.8 mmol/L) is rare. Ketotic hypoglycemia...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Endocrine tumor Multiple endocrine neoplasia type 1 Hypoglycemia Hyperinsulinism Established Facts Neuroendocrine tumors (NETs) in MEN1 are common...

...Merav Gil Margolis; Pearl Lilos; Moshe Phillip; Liat de Vries Introduction: Diagnosing hypoglycemia in infants and children presents significant challenges. Our objective was to elucidate the diagnoses and clinical features of children with hypoglycemia referred to a pediatric endocrine tertiary...

...: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and most severe cause of persistent hypoglycemia in infants and children. In the 65 years since HI in children was first described, there has been a dramatic advancement in the diagnostic tools available...

...Dana Reynolds; Lauren M Mitteer; Winifred Sigal; Linda Boyajian; Heather McKnight; Tricia Bhatti; Lisa States; Susan Becker; N. Scott Adzick; Katherine Lord; Diva D. De Leon Introduction: Hyperinsulinemic hypoglycemia is the most common cause of persistent hypoglycemia in children and adults...

...Paul S. Thornton; Charles A. Stanley; Diva D. De Leon Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly. It was the development of the insulin...

... be the underlying molecular mechanism in some children with HI who have negative genetic testing in peripheral blood DNA. [email protected] 29 06 2022 20 07 2022 11 8 2022 The diagnosis of HI was based on previously described criteria [ 10-12 ]: fasting hypoglycemia accompanied...

... or advertisements. 2022 21-Hydroxylase deficiency Cytochrome P450 family 21 subfamily A member 2 Hydrocortisone replacement Fludrocortisone Modified release hydrocortisone Growth Puberty Stress dosing Adrenal crisis Hypoglycemia Neonatal screening 17-Hydroxyprogesterone Nevanimibe Corticotropin...

...Michal Nevo-Shenker; Shlomit Shalitin Human and experimental animal data suggest both hyperglycemia and hypoglycemia can lead to altered brain structure and neurocognitive function in type 1 diabetes (T1D). Young children with T1D are prone to extreme fluctuations in glucose levels. The overlap...

...Nicole Falzone; Jennifer Harrington Introduction: Hyperinsulinism (HI), the most common neonatal cause of persistent hypoglycemia, can be associated with prolonged hospitalizations and risk for long-term neurological sequelae. Rapid identification of transient versus persistent forms of HI...

... with characterization of the mutation, IGF1R expression, and immune phenotyping. Twin probands presented clinically with short stature and hypoglycemia. Variable phenotypic expression was seen in 2 other family members carrying the IGF1R mutation. The probands were treated with exogenous growth hormone therapy...

..., generally presents peri-pubertally in girls. Case: A 2.8-year-old girl was referred due to recurrent postprandial and fasting hypoglycemia. She had been born at full-term with birth weight 1.89 kg, and had developed transient neonatal diabetes. Examination showed satisfactory growth, reduced adipose tissue...

... the significance of hypoglycemia duration. Methods: We enrolled 85 children and adolescents (36 boys and 49 girls) with type 1 diabetes who used FreeStyle ® Libre in the present study. Frequencies of blood glucose levels as time within target range (TIR; 70–180 mg/dL), time below target range (TBR; <70 mg/dL...

... intermittently, but this does not provide a comprehensive assessment of glycemic control and may fail to detect episodes of hypoglycemia. Objective: To determine whether Dexcom G5®, a continuous glucose monitoring system (CGMS), is an accurate and effective method for monitoring glycemic control in children...

...) vs. at 12 months 39% (95% CI 22—59). No potential adverse events led to discontinuation of IGD. Conclusions: Over a median follow-up of nearly 1 year, IGD was well-tolerated, with no change in WFL-Z or BMI-Z from baseline. Congenital hyperinsulinism Hypoglycemia Nutrition Obesity Intragastric...

... hyperinsulinism Genetics Hypoglycemia Turner syndrome X chromosome Diazoxide Pancreatectomy National Institutes of Health (NIH) 10.13039/100000002 HORMONE RESEARCH IN PÆDIATRIC S Original Paper Horm Res Paediatr 2018;89:413 422 DOI: 10.1159/000488347 Received: November 30, 2017 Accepted...

... adrenal hyperplasia Autoimmune adrenalitis 17-Hydroxyprogesterone Hypoglycemia Treatment monitoring of congenital adrenal hyperplasia (CAH) is controlled by measurements of 17-hydroxyprogesterone (17-OHP), androstenedione, and testosterone concentrations. Guiding symptoms of primary...