... with severe weakness, altered mental status, and syncope in the setting of a venous blood glucose (BG) of 36 mg/dL. Workup showed an elevated insulin level (14 µIU/mL) when BG was 39 mg/dL with positive response to glucagon, concerning for hyperinsulinism. Diazoxide and chlorothiazide were started...

... test, when available. On diagnostic fasting test, a plasma glucose concentration of ≤50 mg/dL (2.8 mmol/L) was considered sufficiently low to elicit the metabolic and neuroendocrine responses required for diagnosis [ 7 ]. Transient HH was retrospectively classified when hyperinsulinism was detected...

...: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and most severe cause of persistent hypoglycemia in infants and children. In the 65 years since HI in children was first described, there has been a dramatic advancement in the diagnostic tools available...

...Kara E. Boodhansingh; Elizabeth Rosenfeld; Katherine Lord; N. Scott Adzick; Tricia Bhatti; Arupa Ganguly; Diva D. De Leon; Charles A. Stanley Introduction: The hyperinsulinemia-hyperammonemia syndrome (HIHA) is the second most common cause of congenital hyperinsulinism and is caused by activating...

...Nicole Falzone; Jennifer Harrington Introduction: Hyperinsulinism (HI), the most common neonatal cause of persistent hypoglycemia, can be associated with prolonged hospitalizations and risk for long-term neurological sequelae. Rapid identification of transient versus persistent forms of HI...

...Arpana Rayannavar; Okan U. Elci; Lauren Mitteer; Diva D. De León Background: Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage. The current monitoring approach involves measuring plasma glucose...

...Paul Thornton; Lisa Truong; Courtney Reynolds; Tyler Hamby; Jonathan Nedrelow Introduction: Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism. Its use has increased over the years to include patients with various genetic...

..., instructions or products referred to in the content or advertisements. 2017 Polycystic ovary syndrome Polycystic ovarian morphology Hyperinsulinism Hirsutism Menstrual irregularities Obesity Insulin sensitizers Anti-androgen Polycystic ovary syndrome (PCOS) is a long-term recognized...

...Onur Akın; Ediz Yeşilkaya; Erkan Sari; Çağdaş Akar; Gökalp Başbozkurt; Enis Macit; Ibrahim Aydin; Abdullah Taşlipinar; Hüsamettin Gül Hyperinsulinism, one of the most important causes of hypoglycaemia, can be congenital or acquired. Rarely, drug toxicity can be a reason for hyperinsulinism...

...Colin Patrick Hawkes; N. Scott Adzick; Andrew A. Palladino; Diva D. De León Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in infants and children. In cases of diazoxide-unresponsive HI, alternative medical and surgical approaches may be required to reduce...

... major adverse events. It seems that octreotide therapy for a short duration is relatively safe. In summary, there is no data on the use of octreotide as a first-line therapy in HH of SGA neonates. The 7 cases of neonatal hyperinsulinism reported here have each been successfully managed...

... with congenital hyperinsulinism (HI), first described in the 1950s by McQuarrie, we examined the genetic locus and clinical phenotype of a novel form of dominant HI. Methods: We surveyed 25 affected individuals, 7 of whom participated in tests of insulin dysregulation (24-hour fasting, oral glucose and protein...

... unresponsive congenital hyperinsulinism (CHI) which requires a near-total pancreatectomy. Methods/Results: A patient born at term with marked macrosomia (5,900 g) presented at the age of 2 h with severe hyperinsulinaemic hypoglycaemia. He failed to respond to treatment with the KATP agonist, diazoxide. An 18F...

... puberty progressed and his body mass index increased. We conclude that, in this patient, metformin had a minimal effect on the hyperinsulinism and none on the acanthosis nigricans in the relatively short term, but further studies in more patients over longer time intervals are warranted. 24 06 1996...

...Selim Kurtoglu; Mustafa Akcakus; Mehmet Keskin; Ahmet Ozcan; Khalid Hussain Hyperinsulinism of infancy is a major cause of persistent hypoglycaemia in the newborn period. Transient mild self-limiting hyperinsulinaemia and hypoglycaemia have been described in neonates born to mothers taking...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hyperinsulinism IGF-I dosing rhIGF-I dosing Pharmacokinetics IGF-I IGFBP HORMONE...

...Karen E. Cosgrove; Ruth M. Shepherd; Eva M. Fernandez; Anuja Natarajan; Keith J. Lindley; Albert Aynsley-Green; Mark J. Dunne Hyperinsulinism in infancy (HI) is a condition of neonates and early childhood. For many years the pathophysiology of this potentially lethal disorder was unknown. Advances...