...-weekly somapacitan, a reversible albumin-binding growth hormone (GH) derivative, in Chinese children with GH deficiency (GHD). Methods: 110 treatment-naïve patients were randomized 2:1 to somapacitan (0.16 mg/kg/week) or daily GH (Norditropin ® ; 0.034 mg/kg/day) for 52 weeks. Annualized height velocity...

... females, treated with IGF-1 from 1998 to 2020. Patients were selected based on criteria including age over 2 years, height standard deviation score (SDS) ≤−2.8, normal or elevated GH secretion (>2.5 ng/mL), IGF-1 levels <50 ng/mL, and insensitivity to exogenous GH. IGF-1 was administered initially...

...Talia Hitt; Kenneth R. Ginsburg; Pamela Cousounis; Terri H. Lipman; Andrew J. Cucchiara; Virginia A. Stallings; Adda Grimberg Introduction: Parents (PP) of children in primary care clinics previously reported factors influencing their height-related medical decision making. However, patients...

... of adult height) in 94 children with ISS followed in the Genetics and Neuroendocrinology of Short Stature International Study, versus 143 controls from the Fels Longitudinal Study. Results: Four variants were nominally associated with ISS using a genotypic model, confirmed by a simultaneous confident...

.... In sub-Saharan Africa, the number of stunted children increased by 12.4 million between 1990 and 2015. Conclusions: Adult height is dependent on nutrition-specific or nutrition-sensitive factors. Nutrition-specific factors can be targeted according to their impact at critical points of development...

... insulin-like growth factor-1 (rhIGF-1) therapy in children. Methods: Safety and effectiveness data on rhIGF-1 treatment of 195 enrolled children with growth failure were collected from December 2008 to September 2013. Results: Mean ± SD (95% CI) height velocity during first year of rhIGF-1 treatment...

...), but a non-significant effect on height gain after pubertal onset (p = 0.32). Important predictors of height gain after puberty onset included gender, age at puberty and number of injections of GH/week. Cost analysis showed that in an average child use of high dose GH, at an extra EUR 5,925 (GBP 4,753/USD...

...A.E.J. Hendriks; M.R. Brown; A.M. Boot; B.A. Oostra; S.L.S. Drop; J.S. Parks Background/Aims: Genetic variation in several candidate genes has been associated with short stature. Recently, a high-mobility group A2 (HMGA2) gene SNP has been robustly associated with height in the general population...

...Markus Perola Over the past 2 to 3 years, linkage disequilibrium mapping methods, or genome-wide association studies (GWAS), have made a seminal turn in the molecular genetic studies of complex human traits such as height, i.e., stature. Human stature is a highly heritable trait across populations...

...) and height (Ht) in adolescence. Methods: Multi-level longitudinal models were used to evaluate growth patterns of 45 salt wasters (SW) and 12 non-SW with CAH. Results: Ht, Wt and BMI growth curves differed between SW and non-SW, and by gender. In contrast to SW and males, non-SW females showed a markedly...

...Joel N. Hirschhorn; Guillaume Lettre Human height (stature) is a strongly genetic trait, with up to 90% of the variation in height within a population determined by a combination of multiple inherited factors. Recent advances in genetics and genomics now permit comprehensive genome-wide surveys...

... composition Weight Height Adiposity Obesity Horm one R e se a rch Body Com position (M ethods and Clinical Value) Horm Res 1997;48(suppl l):33-42 Jan Van den Broeck* b Jan-Maarten With a Bureau of the Dutch Growth Foundation. Sophia Kindcrziekcnhuis, Rotterdam, and b Department of Paediatrics, Leiden...

...-term infants born short for gestational age (GA) ( < -2 standard deviation scores [SDS] in birth length) in two populations. Results from a longitudinal growth study from birth to final height of 139 infants born short for GA between 1973 and 1975 in Göteborg, Sweden, were compared with results from...

...H.J. van der Kamp; F.M.E. Slijper; H. Brandenburg; S.M.P.F. de Muinck Keizer-Schrama; S.L.S. Drop; J.C. Molenaar To evaluate the outcome of medical and surgical treatment of 10 young women with congenital adrenal hyperplasia (CAH), final height, weight, body proportions and body hair growth as well...

... by a slower increase during childhood and puberty. No difference was found between male and female subjects. Apart from age, standardized weight (SDS = z score) had a major positive effect on GHBP concentration. Interestingly, SDS height correlated negatively with GHBP when weight and age were controlled...

...J.P. Bourguignon Based on the analysis of the pubertal growth spurt and final height in different pathological conditions, this paper provides evidence that variations in age at onset of puberty have a major influence on the subsequent acceleration of the growth rate but a minor impact on final...

... the year of GH therapy, although there was considerable individual variation. Progression of BA was not correlated with chronological age, BA, height SD score (SDS) or body mass index SDS at the onset of GH therapy. There was also no consistent effect of the GH dose on BA progression. Conclusion...

...Nadia Qayyum; Lolita Alcocer; Heather Maxwell; T. James Beattie; Anna V. Murphy; Ian J. Ramage; S. Faisal Ahmed Objectives: To assess stature and skeletal disproportion in children with chronic renal disease. Methods: Cross-sectional study of height (HT), sitting height (SH), subischial leg length...

...W.J.M. Gerver; R. de Bruin Normal values are given for height velocity in a Dutch population. A construction of velocity curves is given and a comparison is made with other studies. 28 10 2002 6 06 2003 15 10 2003 Table 2 Comparison of the height measurements...

... the reliability of clinicians’ ‘manual’ evaluation of the adolescent growth spurt from a collected series of height data, and (2) to construct an automated algorithm to determine the duration of the two phases of growth in health and disease (spurt and final slow growth) independent of clinical pubertal stages...