... therapy in a large cohort of LS patients treated at King Faisal Specialist Hospital and Research Center (KFSH & RC), Riyadh, Saudi Arabia over 22 years. Methods: We conducted a retrospective review of medical records for 28 patients with growth hormone insensitivity syndrome, including 12 males and 16...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 STAT5B Growth failure Recombinant human IGF-1 Growth hormone insensitivity Established Facts Patients with homozygous recessive mutations in STAT5B have severe...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Insulin-like growth factor Insulin-like growth factor receptor 1 IGF binding protein Pregnancy associated plasma protein A/A2 Acid labile subunit Growth hormone insensitivity IGF...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Laron syndrome Growth hormone insensitivity Growth hormone receptor GHR mutations Growth hormone insensitivity...

..., an individual trial of GH therapy may be appropriate in these patients. Short stature Growth hormone insensitivity Insulin-like growth factor 1 Insulin-like growth factor 1 receptor gene • Intrauterine and postnatal growth failure due to chromosome 15q26 deletion involving the IGFIR gene causes...

...M.J.E. Walenkamp; J. Klammt; E. Feigerlova; M. Losekoot; H.A. van Duyvenvoorde; V. Hwa; R. Pfäffle; J.M. Wit Background: The work-up of patients with clinical and/or biochemical features of growth hormone insensitivity (GHI) usually contains genetic analysis of the growth hormone receptor (GHR...

... to in the content or advertisements. Exon-intron junctions GHR splicing Insulin-like growth factor-I therapy Growth hormone insensitivity c.784G > C mutation • Growth hormone insensitivity (GHI) syndrome is classically associated with mutations in the GH receptor (GHR) gene, with ∼90...

.... Growth hormone insensitivity Hypoglycemia Hyperglycemia Insulin-like growth factor-I treatment Laron syndrome • Laron syndrome or primary growth hormone receptor insensitivity is a recessive autosomal disease that manifests as insulin-like growth factor-I (IGF-I) deficiency, severe short...

...Silvia Marín; Paula Casano-Sancho; Nancy Villarreal-Peña; Giorgia Sebastiani; Sergio Pinillos; Belén Pérez-Dueñas; Vivian Hwa; Ron G. Rosenfeld; Lourdes Ibáñez Background: Primary growth hormone insensitivity (GHI) and triple A syndrome are rare autosomal recessive disorders. Case Report...

... syndrome Growth hormone therapy Growth hormone insensitivity Growth velocity Turner syndrome Short stature Children with Noonan syndrome (NS) share several dysmorphic features with girls with Turner syndrome. The growth hormone/insulin-like growth factor I (GH-IGF-I) axis has been studied...

... in the IGFALS gene in patients with total ALS deficiency Acid-labile subunit Insulin-like growth factor-I Insulin-like growth factor binding protein Growth hormone insensitivity Insulin insensitivity IGFALS gene mutations The insulin-like growth factor (IGF) system, consisting of 2...

.... Growth hormone Growth hormone binding protein Growth hormone receptor Growth hormone receptor deficiency Growth hormone insensitivity Laron syndrome Session 1: Basic Aspects and Clinical Relevance of Binding Proteins in the Action of GH and IGF-I HormRes 1994;42:129-132 Ron G. Rosenfeld...

...M.B. Ranke; M.O. Savage; P.G. Chatelain; M.A. Preece; R.G. Rosenfeld; W.F. Blum; P. Wilton Thirty-one patients with growth hormone insensitivity syndrome (GHIS) and 2 with GH gene deletion (age 11.2 (3.7-22.9) years; BA (GP) 8.2 years; height -6.5 ± 1.6 SDS) were recruited for the multicenter study...

...Vivian Hwa; Cecilia Camacho-Hübner; Brian M. Little; Alessia David; Lou A. Metherell; Nesrin El-Khatib; Martin O. Savage; Ron G. Rosenfeld Background/Aims: Growth hormone insensitivity (GHI) is characterized by severe short stature, high serum growth hormone (GH), low serum IGF-I and IGFBP-3 levels...

... syndrome Short stature Growth velocity PTPN11 mutations Growth hormone insensitivity Clonidine testing showed a GH peak of 6.1 ng/ml after 60 min, which ruled out GH deficiency in this subject according to our cut-off based on GH response in normal children [ 3 ]. The subject also underwent...

...-I plasma levels is markedly increased, which opens up the possibility that this animal model has a supernormal local IGF-I production and activity. Acid-labile subunit Insulin-like growth factor-I Insulin-like growth factor binding protein Growth hormone insensitivity Pubertal delay...

... between GH levels measured by Nb2 bioassay and GH concentration determined by immunoassay. Growth hormone peak Idiopathic short stature Growth hormone/insulin-like growth factor-I axis Growth hormone insensitivity Growth hormone deficiency (GHD) and GH insensitivity syndrome (GHI...

... growth hormone insensitivity (GHI). Previous reports suggest that heterozygous mutations in the growth hormone receptor gene (GHR) may account for about 5% of children with idiopathic short stature (ISS). In the present study we have attempted to determine whether mutations in the GHR explain the short...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth hormone Growth hormone insensitivity Insulin-like growth factor I Insulin-like growth factor binding protein 3...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. IGF-I Treatment Growth hormone insensitivity Laron syndrome The growth hormone...