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Keywords: Growth hormone deficiencyClose
Aneta Kodytková, Shenali Anne Amaratunga, Daniela Zemková, Klára Maratová, Petra Dušátková, Lukáš Plachý, Štěpánka Průhová, Stanislava Koloušková, Jan Lebl
Horm Res Paediatr 1–8.
Published Online: 23 August 2023
... leading to radial hypoplasia and kidney dystopia in several generations with additional growth hormone deficiency (GHD) in the proband. Case Presentation: Our male proband was born at the 39th week of gestation. He was born small for gestational age (SGA; birth weight 2,550 g, −2.2 SDS; length 47 cm, −2.0...
Nicola Improda, Cristina Moracas, Giuseppina Mattace Raso, Valeria Valente, Giulia Crisci, Paola Lorello, Raffaella Di Mase, Mariacarolina Salerno, Donatella Capalbo
Horm Res Paediatr 1–8.
Published Online: 08 June 2023
...Nicola Improda; Cristina Moracas; Giuseppina Mattace Raso; Valeria Valente; Giulia Crisci; Paola Lorello; Raffaella Di Mase; Mariacarolina Salerno; Donatella Capalbo Introduction: Growth hormone deficiency (GHD) may be associated with subtle cardiovascular abnormalities, reversible upon starting GH...
Horm Res Paediatr 1–7.
Published Online: 28 March 2023
... of therapy she developed remarkable weight gain (+20 kg in 1 year) and growth arrest. Her hormone profile revealed insulin resistance (homeostasis model assessment-estimated insulin resistance [HOMA-IR] 6.8) despite putative growth hormone deficiency (circulating insulin-like growth factor-I [IGF-I] 104 μg/L...
Friedemann Thieme, Mandy Vogel, Ruth Gausche, Christoph Beger, Ioannis-Anargyros Vasilakis, Jürgen Kratzsch, Antje Körner, Wieland Kiess, Roland Werner Pfäffle
Horm Res Paediatr (2022) 95 (5): 452–460.
Published Online: 29 July 2022
... hormone peak Body mass index Growth hormone stimulation test Growth hormone deficiency Children Research Article Horm Res Paediatr 2022;95:452 460 DOI: 10.1159/000526240 Received: February 2, 2022 Accepted: July 24, 2022 Published online: July 29, 2022 The Influence of Body Mass Index on the Growth...
Horm Res Paediatr (2022) 95 (5): 415–422.
Published Online: 30 June 2022
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Metabolic syndrome Growth hormone deficiency Growth hormone therapy...
Altino Sá Meira, Arthur Lyra, Cristiane Kochi, Daniel de Faria Guimarães, Arthur Castello Berchielli Nunes, Guilherme Vieira Peixoto, Stella Gallucci Zamot, Tatiane Sousa e Silva, Antônio José da Rocha, Carlos Alberto Longui
Horm Res Paediatr (2022) 95 (3): 244–254.
Published Online: 02 May 2022
... of the hypothalamic-pituitary region presented as a spectrum from isolated growth hormone deficiency (GHD) to multiple pituitary hormone deficiencies (MPHDs). Our goal was to establish whether the FAST1.2 protocol, which combines the FAST1 protocol with 3D-T2 DRIVE images, could identify the pituitary stalk (PS...
Reiko Horikawa, Toshiaki Tanaka, Yukihiro Hasegawa, Tohru Yorifuji, David Ng, Ron G. Rosenfeld, Yuko Hoshino, Akifumi Okayama, Daisuke Shima, Roy Gomez, Aleksandra Pastrak, Orlando Castellanos
Horm Res Paediatr (2022) 95 (3): 275–285.
Published Online: 13 April 2022
...-weekly treatment for children with growth hormone deficiency (GHD). The objective of this phase 3 study (NCT03874013) was to compare the efficacy and safety of once-weekly somatrogon with once-daily Genotropin in Japanese children with GHD. Methods: In this open-label, randomized, active-controlled study...
Aristides K. Maniatis, Ulhas Nadgir, Paul Saenger, Kent L. Reifschneider, Jennifer Abuzzahab, Larry Deeb, Larry A. Fox, Katie A. Woods, Wenjie Song, Meng Mao, Steven D. Chessler, Allison S. Komirenko, Aimee D. Shu, Samuel J. Casella, Paul S. Thornton
Horm Res Paediatr (2022) 95 (3): 233–243.
Published Online: 09 March 2022
... the safety and tolerability of once-weekly lonapegsomatropin, a long-acting prodrug, in children with growth hormone deficiency (GHD) who switched from daily somatropin therapy to lonapegsomatropin. Methods: This multicenter, open-label, 26-week phase 3 trial took place at 28 sites across 4 countries...
Horm Res Paediatr (2023) 96 (6): 553–559.
Published Online: 25 February 2022
.... 2022 Growth hormone Long-acting growth hormone Growth Short stature Growth hormone deficiency Growth hormone therapy Since 1985, recombinant human growth hormone (rhGH) has been used for the treatment of GH deficiency (GHD). Efficacy and safety of rhGH administered daily have been...
Horm Res Paediatr (2022) 94 (11-12): 399–405.
Published Online: 02 December 2021
...George M. Bright; Peter A. Morris; Ron G. Rosenfeld Background: In most cases, the growth hormone stimulation test is a necessary component for the diagnosis of growth hormone deficiency (GHD) in children. Diagnostic testing can lead to unnecessary treatment of children with false-positive test...
Violetta Csákváry, Nicola Ammer, Ekaterine Bakhtadze Bagci, Olena V. Bolshova, Birgitte Bentz Damholt, Dragan Katanic, Evgenia Mikhailova, Ágota Muzsnai, Dmitri Raduk, Ganna Senatorova, Mieczysław Szalecki, Michael Teifel, Zsolt Vajda, Nataliya Zelinska, Tetyana Chaychenko
Horm Res Paediatr (2021) 94 (7-8): 239–250.
Published Online: 26 August 2021
...: Diagnosis of growth hormone deficiency (GHD) in children requires the use of provocative growth hormone (GH) stimulation tests, which can have limited reliability and are potentially contraindicated in some patients. This is the first paediatric study to test the safety, tolerability, and pharmacokinetics...
Toshiaki Tanaka, Shun Soneda, Naoko Sato, Kentaro Kishi, Masahiro Noda, Atsuko Ogasawara, Osamu Nose, Yukiko Nakano, Eiichi Kinoshita, Takahiro Mochizuki, Susumu Konda, Mari Murashita, Takakuni Tanizawa, Hiroki Nozue, Masakuni Tokuda, Kazuoki Kubota, Kumiko Araki, Sachiko Kitanaka, Hiroaki Inomata, Chuken Miyagi, Katsura Ishizu, Shinichiro Miyagawa
Horm Res Paediatr (2021) 94 (5-6): 211–218.
Published Online: 23 August 2021
... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Short stature Growth hormone deficiency...
Horm Res Paediatr (2021) 94 (5-6): 201–210.
Published Online: 23 August 2021
...Abdullah Almaghraby; Alok Jaju; Maura E. Ryan; Karen Rychlik; Reema L. Habiby; Wendy J. Brickman Introduction: Short stature is a common concern that necessitates pediatric endocrinology evaluation. Growth hormone deficiency (GHD) is a commonly considered etiology. Brain and pituitary magnetic...
Horm Res Paediatr (2021) 94 (1-2): 9–17.
Published Online: 24 June 2021
..., instructions or products referred to in the content or advertisements. Langerhans cell histiocytosis Central diabetes insipidus Pediatric endocrine dysfunction Growth hormone deficiency Langerhans cell histiocytosis (LCH) is a disorder with elusive aetiology, of the mononuclear phagocyte...
Horm Res Paediatr (2021) 93 (7-8): 470–476.
Published Online: 10 February 2021
...Michal Yackobovitch-Gavan; Liora Lazar; Rotem Diamant; Moshe Phillip; Tal Oron Introduction: The diagnosis of childhood growth hormone deficiency (GHD) requires a failure to respond to 2 GH stimulation tests (GHSTs) performed with different stimuli. The most commonly used tests are glucagon...
Diana-Alexandra Ertl, Jiajia Chen, Andreas Gleiss, Dominik Janu, Susanne Sagmeister, Adalbert Raimann, Stefan Riedl, Gabriele Haeusler
Horm Res Paediatr (2021) 93 (6): 371–379.
Published Online: 18 December 2020
... for growth hormone deficiency (GHD). The aim of the study is to evaluate the relevance of serum ALS as an additional biomarker in the diagnosis of GHD. Methods: Ninety-one children undergoing standard diagnostic work-up for GHD were included in this retrospective study. Inclusion criteria were evidence-based...
Roland Pfäffle, Martin Bidlingmaier, Ilonka Kreitschmann-Andermahr, Christof Land, Carl Joachim Partsch, Karl Otfried Schwab, Heide Sommer, Philippe Backeljauw, Shankar Kanumakala, Sandro Loche, Hichem Zouater, Christian J. Strasburger
Horm Res Paediatr (2020) 93 (3): 154–163.
Published Online: 19 August 2020
.... Results: As of November 2017, 6,009 patients from 298 centers across 14 countries were enrolled in PATRO Children. Overall, 57.7% of patients had growth hormone deficiency (GHD), 25.8% were born small for gestational age (SGA), and 4.8% had Turner syndrome (TS). In total, 84.1% were rhGH treatment naïve...
Thais H. Inoue-Lima, Gabriela A. Vasques, Marilena Nakaguma, Luciana Pinto Brito, Berenice B. Mendonça, Ivo J.P. Arnhold, Alexander A.L. Jorge
Horm Res Paediatr (2020) 93 (3): 197–205.
Published Online: 14 August 2020
...Thais H. Inoue-Lima; Gabriela A. Vasques; Marilena Nakaguma; Luciana Pinto Brito; Berenice B. Mendonça; Ivo J.P. Arnhold; Alexander A.L. Jorge Background: The utility of insulin-like growth factor type 1 (IGF-1) is well established in the diagnosis of growth hormone deficiency (GHD), whereas IGF...
Sarah Castets, Florence Roucher-Boulez, Alexandru Saveanu, Delphine Mallet-Motak, Olivier Chabre, Patrizia Amati-Bonneau, Dominique Bonneau, Celine Girardin, Yves Morel, Carine Villanueva, Thierry Brue, Rachel Reynaud, Marc Nicolino
Horm Res Paediatr (2020) 93 (1): 30–39.
Published Online: 26 May 2020
..., and epicanthus inversus syndrome (BPES). There have been few single case reports of growth hormone deficiency (GHD) with this syndrome, and Foxl2 is known to be involved in pituitary development in mice. Our aim was to analyze the prevalence of FOXL2 gene alteration in a series of patients with congenital...
Tamar G. Baer, Sanchita Agarwal, Shaoxuan Chen, Codruta Chiuzan, Aviva B. Sopher, Rachel Tao, Abeer Hassoun, Elizabeth Shane, Ilene Fennoy, Sharon E. Oberfield, Patricia M. Vuguin
Horm Res Paediatr (2020) 92 (5): 293–301.
Published Online: 04 May 2020
..., instructions or products referred to in the content or advertisements. 2020 Growth hormone deficiency Bone HR-pQCT Pediatric endocrinology NIH Although growth hormone (GH) is responsible for longitudinal bone growth, it also plays an important role in building and maintaining...