.... 2023 Prader-Willi syndrome Children Infants Growth hormone Ghrelin Prader-Willi syndrome (PWS) is a rare syndrome caused by the lack of expression of the paternally derived chromosome 15q11-q13, due to a paternal deletion or maternal uniparental disomy, and in rare cases...

...Régis Coutant; Bruno Leheup; Marc Nicolino; Jean-Pierre Salles Introduction: Growth hormone (GH) therapy improves height outcomes in short children born small for gestational age (SGA); however, real-world data on long-term GH exposure are few. Methods: We report results from an observational study...

... it and distinguish it from other anterior pituitary hormones. With relatively pure growth hormone (GH), its biological activity in growth promotion and as a metabolic hormone were studied, and species specificity became apparent: primate GH was the only GH active in man. Human GH was prepared from cadaveric...

...Reiko Horikawa; Toshiaki Tanaka; Yukihiro Hasegawa; Tohru Yorifuji; David Ng; Ron G. Rosenfeld; Yuko Hoshino; Akifumi Okayama; Daisuke Shima; Roy Gomez; Aleksandra Pastrak; Orlando Castellanos Introduction: Somatrogon is a long-acting recombinant human growth hormone being developed as a once...

... the safety and tolerability of once-weekly lonapegsomatropin, a long-acting prodrug, in children with growth hormone deficiency (GHD) who switched from daily somatropin therapy to lonapegsomatropin. Methods: This multicenter, open-label, 26-week phase 3 trial took place at 28 sites across 4 countries...

...Valentina Pampanini; Annalisa Deodati; Elena Inzaghi; Stefano Cianfarani Background: Daily recombinant human growth hormone (rhGH) is approved and marketed worldwide to treat children and adults with GH deficiency and other conditions. Efficacy of rhGH therapy is influenced by several variables...

...George M. Bright; Peter A. Morris; Ron G. Rosenfeld Background: In most cases, the growth hormone stimulation test is a necessary component for the diagnosis of growth hormone deficiency (GHD) in children. Diagnostic testing can lead to unnecessary treatment of children with false-positive test...

...David B. Allen; Nadia Merchant; Bradley S. Miller; Philippe F. Backeljauw Background: Longitudinal bone growth is regulated by multiple endocrine signals (e.g., growth hormone, insulin-like growth factor I, estrogen, and androgen) and local factors (e.g., fibroblast growth factors...

... of this study was to evaluate catch-up growth and cardiovascular markers before and during growth hormone (rhGH) treatment in KS children. Methods: This prospective study included 18 children whose KS was genetically established. Each KS subject received rhGH for a period of 2 years. Several measurements were...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2021 Turner syndrome Childhood Growth hormone Near-adult height Final...

..., instructions or products referred to in the content or advertisements. Juvenile Paget disease Denosumab Bisphosphonates Growth hormone Linear growth Height velocity Receptor activator of nuclear factor-κB ligand Juvenile Paget Disease (JPD) is an ultra-rare, severe skeletal disease...

...Denver D. Brown; Andrew Dauber Poor growth is a common finding in children with chronic kidney disease (CKD) that has been associated with poor long-term outcomes. The etiology of poor growth in this population is multifactorial and includes dysregulation of the growth hormone (GH) and insulin-like...

...Elodie Adler; Anne-Sophie Lambert; Claire Bouvattier; Cécile Thomas-Teinturier; Anya Rothenbuhler; Paul de Boissieu; Agnès Linglart Introduction: About 8% of children born small for gestational age (SGA) do not reach a final height within the normal range. Recombinant human growth hormone (rhGH...

...Jan M. Wit; Sjoerd D. Joustra; Monique Losekoot; Hermine A. van Duyvenvoorde; Christiaan de Bruin The current differential diagnosis for a short child with low insulin-like growth factor I (IGF-I) and a normal growth hormone (GH) peak in a GH stimulation test (GHST), after exclusion of acquired...

...Anders Tidblad; Jan Gustafsson; Claude Marcus; Martin Ritzén; Klas Ekström Introduction: Growth hormone (GH) is a central hormone for regulating linear growth during childhood and also highly involved in the metabolism of lipids, carbohydrates, and protein. However, few studies report on how...

... in seeking medical care for their child’s height with identical questions previously asked of PP and two additional questions about growth hormone (GH) treatment. Results: A greater proportion of the 166 EP (80% response rate) than the 1,820 PP (83% response rate) previously surveyed was Caucasian (75% EP...

..., thereby exerting a strong influence on regulatory gene networks. Increasing studies suggest the importance of miRNAs in the regulation of the growth plate and growth hormone (GH)-insulin-like growth factor (IGF) axis during the life course in a broad spectrum of animal species, contributing...

... of diagnostic techniques has led to the discovery of causal mutations in genes involved in the function of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis as well as in growth plate physiology. However, many cases of ISS remain idiopathic. In the future, the more frequent identification...

... Saenger; Jan M. Wit; Joachim Woelfle The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists...

...Judith S. Renes; Jaap van Doorn; Anita C.S. Hokken-Koelega Background: The reason for the insufficient catch-up growth seen in 10% of children born small for gestational age (SGA) is poorly understood. Disturbances in the growth hormone (GH) – insulin-like growth factor (IGF) axis might underlie...