... in pediatric endocrinology clinics. During the last 3 decades, numerous monogenic causes of growth disorders and the molecular bases of many syndromes have been described [ 1 ]. When dealing with a patient with short stature and MCPH, the approach must be different, and genes known to cause Seckel syndrome...

...Peter Lauffer; Gerdine A. Kamp; Leonie A. Menke; Jan M. Wit; Wilma Oostdijk; on behalf of the Dutch Working Group on Triage and Diagnosis of Growth Disorders in Children Tall stature and/or accelerated growth (TS/AG) in a child can be the result of a primary or secondary growth disorder, but more...

...Jan M. Wit; Gerdine A. Kamp; Wilma Oostdijk; on behalf of the Dutch Working Group on Triage and Diagnosis of Growth Disorders in Children Based on a recent Dutch national guideline, we propose a structured stepwise diagnostic approach for children with growth failure (short stature and/or growth...

...-being of the child. Despite late diagnosis being common in growth disorders, programmes of height screening in primary care are not universal in developed countries and may be random or non-existent. A notable exception is automated growth monitoring in Finland, where an algorithm to detect abnormal...

... with growth failure (17.6%): a primary growth disorder in 8 children and a secondary growth disorder in 15 (table 1 ; fig. 1 ). Five of the 23 patients presented with an HSDS ≥-2.0. Among the 69 patients with an HSDS <-2.0, no specific diagnosis could be made in 51 patients (73.9%), and they were thus...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Growth disorders Glucose intolerance Growth hormone Monogenic forms of growth hormone insensitivity (GHI) and its treatment with insulin...

...A. Stevens; C. De Leonibus; A. Whatmore; D. Hanson; P. Murray; P. Chatelain; M. Westwood; P. Clayton Growth disorders resulting in short stature are caused by a wide range of underlying pathophysiological processes. To improve height many of these conditions are treated with recombinant human...

..., instructions or products referred to in the content or advertisements. Growth hormone Silver-Russell syndrome Adult height Growth disorders Genetics of short stature Children with Silver-Russell syndrome (SRS) are among the very short seen in pediatric practice. SRS is defined as intrauterine...

.... Head circumference-to-height ratio Growth/auxology Growth disorders Neurofibromatosis type 1 Body proportions The assessment of growth in children is a well-established and cost-effective part of the preventive health care services provided in the majority of developed countries [ 1,2...

.... Growth hormone GH/IGF-1 axis Growth disorders IGF-1 Growth hormone receptor GH1 gene Genetics STAT5B Acid-labile subunit In approximately 80% of children who are referred to a pediatric clinic because of short stature, no definite cause can be established, even after a thorough...

.... 2011 Short stature Growth disorders Diagnostic workup Short stature is one of the most common conditions presented to pediatric endocrinologists and pediatricians. The diagnostic approach to short stature in children has been the subject of much debate [ 1, 2, 3, 4 ]. To ensure...

... nationwide survey performed in 1997 (n = 14,500), we calculated correlations for different ages, and fitted a regression model for the estimation of HC. HC versus height charts were created for different age groups. Data from children from other ethnic groups and children with various growth disorders were...

... = small for gestational age. When a child is referred to a pediatrician, the diagnostic process is aimed at detecting the cause of his/her shortness. In most diagnostic classifications, including the ESPE Classification of Paediatric Endocrine Diagnoses, three main groups of growth disorders...

...P. Georges; J. Liefooghe; D. Ponchaux; G. Forzy; L. DiNicola; J.L. Chaussain Urinary growth hormone excretion (uGH), expressed as the average of three consecutive nocturnal measurements, was studied in 324 prepubertal and pubertal children without (n = 188) or with (n = 136) growth disorders...

..., instructions or products referred to in the content or advertisements. Growth hormone Growth hormone deficiency Growth disorders Growth hormone therapy Original Paper Horm Res 1993;40:123-127 D. Zantleifer S. Awadalla R. Bram er Paediatric Endocrinology Unit, Hôpital et Faculté Ncckcr Enfants...

... factors Growth disorders Original Paper Horm Res 1993;40:136-140 H. Thibault J.C. Souberbielle C. Taieb R. Brauner Paediatric Endocrinology Unit and Physiology Laboratory. Hôpital et Faculté Necker Enfants Malades, Paris, France Idiopathic Prepubertal Short Stature Is Associated with Low Body Mass...

.... Receiver-operated characteristic curve analysis Growth hormone 24-hour spontaneous secretion Growth disorders Peak detection efficacy PULSAR CLUSTER Original Paper Horm Res 1994;41:169-176 BeriholdP. Hauffa Herbert Stolecke Department of Pediatric Endocrinology. University Children s Hospital...

...Werner F. Blum; Michael B. Ranke A specific radioimmunoassay for insulin-like growth factor-binding protein 3 (IGFBP-3), developed against its binding subunit (IGFBP-3β), was used to investigate its diagnostic potential for the evaluation of growth disorders. Various factors were found to influence...

.... Growth disorders Pituitary diseases Growth hormone Somatotropin Prolactin Thyrotropin Hypothyroidism Somatostatin Hereditary diseases Horm Res 1989;32:170-177 © 1989 S. Karger AG, Basel 0301-0163/89/0326-0170S2.75/0 Total Deficiency of Growth Hormone and Prolactin, and Partial Deficiency...

.... Somatotropin Growth hormone releasing factor Growth disorders Growth hormone deficiency Knemometry Original Papers Hormone Res. 27: 181-189 (1987) © 1987 S. Karger AG. Basel 0301 -0163/87/0274-0181 $2.75/0 Short-Term Effect on Growth of Two Doses of GRF 1-44 in Children with Growth Hormone Deficiency...