... of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provides additional health benefits but can cause glucose fluctuations, which challenges current AID systems. While an increasing number of clinical trials...

...Alaina P. Vidmar; Choo Phei Wee; Sarah-Jeanne Salvy; Jomanah Abduljalil Bakhsh; Michael I. Goran Introduction: To date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept study...

... show there may be an impact on glycaemic control in those with CF-related diabetes (CFRD). Paediatric data are rare. Case Series/Presentation: Children aged >12 years with CFRD, who were eligible for elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) were commenced on treatment. Glucose monitoring via...

.... Pancreas Hypoglycemia Beta cells Infants Insulin Glucose Hypoglycemia was first revealed as a human disorder in 1922 when one of the initial patients treated with Banting and Best’s insulin started “climbing the walls” as a consequence of low plasma glucose [1]. Shortly thereafter, endogenous...

... healthy controls (HC) matched on pubertal status. Each subject had a history, physical exam, and oral glucose tolerance test (OGTT). Oral glucose and c-peptide minimal modeling was used to determine β-cell function. Results: Twenty-one TS girls (35%) met criteria for prediabetes. Impaired fasting glucose...

... frequency of hypoglycaemic episodes associated with an increase in the intravenous glucose infusion rate required to maintain normoglycaemia. When the diazoxide was stopped, the intravenous glucose infusion rate decreased and the frequency of hypoglycaemic episodes significantly reduced. The period between...

... to in the content or advertisements. Congenital hyperinsulinism Hypoglycemia Glucose 18 F-DOPA Mutational analysis was performed as described previously [ 12 ]. Briefly, all exons and the exon-intron boundaries of the KCNJ11 , ABCC8 , and GCK genes were amplified from leukocyte genomic DNA...

... required 20 mg/kg/min of glucose intravenously to maintain normoglycaemia. A hypoglycaemia screen confirmed hyperinsulinaemic hypoglycaemia with an elevated serum insulin level of 169 pmol/l with a simultaneous blood glucose concentration of 2.0 mmol/l (with suppressed serum fatty acids and ketone bodies...

...G. Winiger; U. Keller; R. Laager; J. Girard; W. Berger The effect of two isocaloric evening meals (low protein-high fat vs. high protein-low fat content) on plasma glucose regulation during the night were compared. Eight C-peptide-defïcient type-I diabetic subjects without autonomic neuropathy were...

... adenomas. Octreotide caused a significant decrease of GH and IGF-I levels in all the patients and no significant change in thyroid, adrenal and gonadal function. In contrast, during the therapy, the glucose response to an oral glucose tolerance test considerably increased and was delayed, while the insulin...

...Gunnar Engström; Per Lindström; Lars Sävendahl Growth hormone (GH) is diabetogenic but has also been suggested to stimulate insulin release. Our aim was to study whether acute effects of GH on serum insulin and glucose concentrations can be observed when GH release is physiologically induced by GH...

... to alternate substrate forms. Carbohydrate is transported to the fetus as glucose which is taken up from the maternal plasma by the GLUT 1 transporter and transported to the fetus by facultative diffusion according to concentration-dependent kinetics. Protein is transported to the fetus as amino acids...

... in the presence of less than 0.25% albumin but subsequently increased 2.8-, 4.8-and 5.6-fold in the presence of 0.25, 0.50 and 1.0% albumin, respectively. In the absence of added insulin, increased activity of the insulin-stimulated utilization of glucose by both extracts was observed but only Brewer’s yeast...

...Charles Couet; Jacques Delarue; Thierry Constans; Fernand Lamisse Impaired glucose tolerance occurs with age. This impairment is multifactorial including a decrease in insulin-mediated glucose uptake by peripheral tissues and a delay in insulin-induced suppression of hepatic glucose output. A post...

...P.M.J. Zelissen; H.P.F. Koppeschaar; J.H.H. Thijssen; D.W. Erkelens The responses of plasma β-endorphin, insulin and glucose to two different isocaloric mixed meals – high carbohydrate (CHO meal) and high fat (fat meal) – were assessed in women with android obesity before (n = 11) as well as after...

... of IL-1 to affect glucose homeostasis. In normal mice, low doses of IL-1 induce a long-lasting hypoglycemia which is not dependent on possible insulin-secretagogue actions of this cytokine. The hypoglycemic effect of IL-1 is also observed in insulin-resistant diabetic mice. Furthermore, IL-1 seems...

...%) phosphorylation of three peptides of molecular masses 39,000, 29,000 and 21,000 daltons. Glucose (5–50 m M) stimulated the phosphorylation of one peptide of molecular mass 19,000 daltons by 24%. 22 07 1985 14 02 1986 28 11 2008 © 1986 S. Karger AG, Basel 1986 Copyright / Drug Dosage...

... to either an elevation of the glucose concentration or the administration of carbamylcholine or arginine. The difference between the ventral and dorsal response was less marked at low glucose concentrations (3.3 or 7.0 mmol/l) and, possibly, in response to glucagon. In the case of glucagon release...

... to intravenous glucose administration (0.33 g/kg) in basal condition and after the injection of 3 IU (1 plus 2 IU/1 h) or 6 IU (2 plus 4 IU/ 1 h) of oxytocin (6 subjects for each group). The highest dose of oxytocin (6 IU) used significantly increased insulin secretion in response to intravenously administered...

...-dependent) diabetic couples compared to 14 healthy subjects without family history of diabetes mellitus. The two groups, each consisting of 5 obese and 9 nonobese subjects, were carefully matched for sex, age, and body weight. We examined glucose, insulin, and C-peptide levels, as well as C-peptide...