... to excessive weight gain and hyperphagia in early childhood. An elevated, more unfavorable ratio between acylated and unacylated ghrelin (AG/UAG ratio) might play a role in the underlying mechanisms of this switch. We aimed to assess the evolution of the appetite-regulating hormones acylated ghrelin (AG...

...Liina Remmel; Vallo Tillmann; Jarek Mäestu; Priit Purge; Meeli Saar; Evelin Lätt; Katre Maasalu; Toivo Jürimäe; Jaak Jürimäe Background/Aims: The role of ghrelin and peptide YY (PYY) in bone mineralization is not fully known. The aim of this study was to determine whether acylated and des-acyl...

... is unknown. We investigated serum leptin and plasma ghrelin levels before and 1 year after (adeno)tonsillectomy operation in children. Materials and Methods: We studied 31 patients and 29 age- and sex-matched healthy control children. Auxologic evaluation and biochemical investigations were performed before...

... bariatric surgery. Case: A 15-year-old obese female (BMI 42.2) who was unresponsive to medical treatment underwent gastroplication. Hunger hormone levels (leptin, ghrelin and insulin), weight loss and eating behavior were monitored at 3, 6 and 12 months after surgery. Results: Weight loss was obtained...

...Chuan Shen; Tao Yu; Zhang Hui Tang; Kang Min Wu Background: Obestatin and ghrelin both have effects on the hypothalamus which controls food intake. We hypothesize that the circulating levels of obestatin and ghrelin may change after a meal and might be different between obesity and anorexia, which...

...F. Savino; S. Benetti; M.M. Lupica; E. Petrucci; E. Palumeri; L. Cordero di Montezemolo Aim: To investigate the role of ghrelin and obestatin in infancy. Methods: We measured ghrelin and obestatin concentrations in blood samples of infants, lactating mothers, and in breast milk. Results: The median...

...Anna-Liisa Parm; Jaak Jürimäe; Meeli Saar; Kristel Pärna; Vallo Tillmann; Katre Maasalu; Inga Neissaar; Toivo Jürimäe Aim: Relationships between change of bone mineral density (BMD) and baseline adipocytokine and ghrelin levels over 12 months in prepubertal rhythmic gymnasts (RG) and age-matched...

... of glucose, insulin, cortisol, leptin, neuropeptide Y (NPY), galanin and ghrelin were assessed before (month 0) and after 18 months of therapy. Eighteen age- and gender-matched patients (10.78 ± 3.95 years) were enrolled as the control group. Results: Excess per capita weight of 2.3 kg was determined...

...Germán Iñiguez; Rossana Román; Ronald Youlton; Fernando Cassorla; Verónica Mericq Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate...

...M. Lodefalk; C. Carlsson-Skwirut; J.J. Holst; J. Åman; P. Bang Aims: To compare the responses of GIP, GLP-1, ghrelin and IGFBP-1 between meals with different fat and energy content in adolescents with type 1 diabetes (T1DM) and to relate them to gastric emptying and glycaemia. Methods: On different...

...Aart Jan van der Lely Background: A growing body of literature has profiled the complex identities and interactions of ghrelin analogues and their known and unknown receptors, which constitute the ghrelin system. In humans, acylated ghrelin (AG) induces a rapid rise in glucose and insulin levels...

...June Carnier; Mara C. Lofrano; Wagner L. Prado; Danielle A. Caranti; Aline de Piano; Lian Tock; Claudia M.O. do Nascimento; Lila M. Oyama; Marco T. Mello; Sérgio Tufik; Ana R. Dâmaso Background/Aims: Ghrelin and leptin play important roles in the physiopathology of eating disorders, starting...

... with increased hunger and with alterations in parameters of glucose tolerance suggestive of an increased risk of diabetes. Epidemiologic findings in both children and adults are consistent with the laboratory data. 15 2 2007 Ghrelin Leptin Insulin resistance Obesity Diabetes It has been...

... for auxology and IGF-I, IGFBP-3, leptin, ghrelin, adiponectin, lipids and OGTT results in a prospective multicenter study. Intervention: GH (Genotropin®) in a dose of 50 µg/kg/day for 1 year. Results: Height standard deviation score (SDS) increased from –3.9 ± 1.5 to –3.5 ± 1.4 (p = 0.000) on therapy. BMI did...

...Natacha Bouhours-Nouet; Florence Boux de Casson; Stéphanie Rouleau; Olivier Douay; Elisabeth Mathieu; Claude Bouderlique; Philippe Gillard; Jean Marie Limal; Philippe Descamps; Régis Coutant Aims: To investigate the role of ghrelin in maternal and fetal metabolism, we determined its value...

...Alev E. Altınova; Füsun B. Törüner; Müjde Aktürk; Şehri Elbeğ; İlhan Yetkin; Nuri Çakır; Metin Arslan Background and Objective: Recent studies have revealed that circulating ghrelin levels seem to play a role in energy homeostasis. The effect of hyperthyroidism on ghrelin levels is not fully known...

...Hisafumi Matsuoka; Hiroshi Hosoda; Hisae Sugawara; Saika Iwama; Hye Sook Kim; Kenji Kangawa; Shigetaka Sugihara Background and Objective: Ghrelin is a novel gastric peptide which stimulates GH secretion and has been demonstrated to have orexigenic and adipogenic properties. Insulin...

...Denton Hirsh; Claudine Heinrichs; Bert Leenders; Alfred C.K. Wong; David E. Cummings; Jean-Pierre Chanoine Background: Glucagon stimulation is routinely used as a provocative test to assess growth hormone (GH) sufficiency in pediatrics. Ghrelin also markedly stimulates GH secretion. Because...

...J.-P. Chanoine Exogenous administration of ghrelin increases caloric intake and stimulates growth hormone (GH) secretion, two effects that are mediated through binding of ghrelin to the GH secretagogue receptor (GHS-R). In addition, ghrelin is thought to inhibit adipogenesis by GHS-R-independent...

... of the orphan GPCR, i.e. a GPCR with no known natural ligand, until we purified its endogenous ligand from rat stomach and named it ‘ghrelin’. Ghrelin is a 28-amino-acid peptide, in which the serine 3 is modified by an n-octanoic acid and this modification is essential for ghrelin’s activity. The discovery...