...Markus Perola Over the past 2 to 3 years, linkage disequilibrium mapping methods, or genome-wide association studies (GWAS), have made a seminal turn in the molecular genetic studies of complex human traits such as height, i.e., stature. Human stature is a highly heritable trait across populations...

... will then discuss the present and future implications of these findings with regards to disease prediction, uncovering basic biology, and the development of novel therapeutic agents. Endocrinology Genetics Genome-wide association studies Pediatrics Prior to embarking on the individual topic reviews, we...

..., adequate power is essential to avoid false negatives. A review of association studies and subsequent experience with genome-wide association studies suggest that most common genetic variants that influence polygenic traits will have modest effects. Thus, large sample sizes and combined consideration...