... patients and after the onset of T1DM in 8). Height SDS patterns during GH therapy in the 11 patients affected by GH deficiency ranged from -0.3 to +3.1 SDS. In the 8 diabetic patients in whom GH was added subsequently, mean insulin dose increased during the first 6 months of therapy from 0.7 ± 0.2 to 1.0...

... ventricular mass concentric hypertrophy. Conversely, patients with childhood or adult-onset GH deficiency (GHD) have a reduced left ventricular mass (LVM) and ejection fraction (EF) and the indices of left ventricular systolic function remained markedly depressed during exercise. Cardiac function is reported...

...Anders Juul; Jens Otto L. Jørgensen; Jens S. Christiansen; Jørn Müller; Niels E. Skakkebœk GH deficiency in children has been treated for decades with GH in order to normalize growth and final height. After cessation of linear growth GH treatment has traditionally been stopped. However, adults...

...L.A. Pérez Jurado; J. Argente A significant proportion of cases of GH deficiency (5-30%) may be due to genetic causes. At least four Mendelian types of isolated GH deficiency (IGHD) have been delineated based on the mode of inheritance and the degree of GH deficiency: IGHD type I A, autosomal...

...), and growth failure (n = 1). During periods of 1-5 years per child, the following abnormalities developed: diabetes insipidus (n = 5), osmoreceptor dysfunction (hypernatraemia with absent thirst) (n = 3), hyperprolactinaemia (n = 3), growth hormone (GH) deficiency (n = 4, of whom 3 had normal linear growth...

.../kg/week) resulted in an increase in growth velocity from 4.9 ± 1.2 to 6.8 ± 2.2 cm/year. These results are comparable to those of a group with total GH deficiency receiving the same dose. Analysis of the results showed a group of good responders (n = 14, growth velocity: 8.1 cm/year) and a group...

... basis. Methods: Fifty pre-pubertal patients with short stature (height ≤–2 SDS and GV ≤–1.2 SDS) were studied. GH deficiency (GHD) was diagnosed in 39 patients, on the basis of clinical and auxological parameters and on the serum concentration of IGF-1, and non-GHD in the other 11 patients. Two PhT GH...

... concentrations during the initial phase of GH treatment. Methods: Our investigation was part of the regular follow-up of prepubertal children with GH deficiency (GHD) (n = 31) and small for gestational age (SGA) (n = 23). Dosage was increased in three steps: one-third at the start, two-thirds after 14 days...

...) treatment for GH-deficient (GHD) children is approved in most countries. However, diagnostic criteria and treatment modalities differ between countries. In this study, diagnostic criteria and treatment modalities were investigated by questionnaire from 11 countries and compared with those used in Japan...

...Anders Juul Insulin-like growth factor (IGF)-I has proven to be important in the diagnosis of childhood-onset growth hormone (GH) deficiency (GHD). However, the variability of IGF-I should be taken into account before it can be used in a clinical setting. GH replacement therapy in GHD patients...

... to growth hormone (GH) treatment in a slowly growing child with GH deficiency (GHD) or in a child with idiopathic short stature (ISS). The growth response to the standard dose of GH can be regarded as a bioassay for GH (i.e. the tissue GH responsiveness) and the information on this growth response can...

...Anders Juul; Sergio Bernasconi; Peter E. Clayton; Wieland Kiess; Sabine DeMuinck-Keizer Schrama Background: The present survey among members of the ESPE on current practice in diagnosis and treatment of growth hormone (GH) deficiency (GHD) is of great clinical relevance and importance in the light...

.... Combined pituitary hormone deficiency GH deficiency PROP-1 gene Growth patterns Pituitary MRI Combined pituitary hormone deficiency (CPHD) is characterized by impaired secretion of GH and one or more of the other five anterior pituitary hormones. Pituitary function depends on the integrity...

... and end of therapy in the first two subgroups, with a similar duration of therapy. Severe GH deficiency (GHD) [both multiple pituitary hormone deficiency (MPHD) and the most severe isolated GHD (IGHD-A)] was more frequent in the group ending treatment at ‘near-final height’, whereas cessation of therapy...

..., instructions or products referred to in the content or advertisements. Pituitary Panhypopituitarism Pit-1 Congenital hypothyroidism Growth retardation Pituitary transcription factor Gene mutation GH deficiency Growth retardation is a major and frequent complaint among children...

... evaluation GH deficiency Idiopathic short stature Insulin-like growth factors IGF-binding proteins GH treatment Height was measured using a Harpenden stadiometer. Height standard deviation scores (SDS) were calculated using the Dutch nationwide references [ 24 ]. Height velocity before...