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Keywords: Epigenetics
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Journal Articles
Horm Res Paediatr (2022) 95 (2): 112–119.
Published Online: 10 November 2021
... in the contribution to later obesity development is presented. Maternal pre-pregnancy BMI and gestational weight gain have been pointed out as independent determinants of infant later adiposity. Lifestyle interventions could have an impact on pregnant mothers through epigenetic mechanisms capable of redirecting...
Journal Articles
Horm Res Paediatr (2018) 89 (5): 331–340.
Published Online: 09 May 2018
... governing adrenal zonation, particularly postnatal zona reticularis development, which produce adrenal androgens in a lifetime-specific manner, remain poorly understood. Epigenetic events, including DNA and histone modifications as well as regulation by noncoding RNAs, are crucial in establishing...
Journal Articles
Horm Res Paediatr (2017) 88 (3-4): 181–193.
Published Online: 28 August 2017
.... Epigenetics and gestational programming, especially the role of microRNA, comprise a novel, rapidly developing and promising research focus on the topic of MetS. MicroRNAs are increasingly valued for potential roles in the diagnosis, stratification, and therapeutics of MetS. Early detection of risk factors...
Journal Articles
Horm Res Paediatr (2016) 85 (6): 363–371.
Published Online: 10 March 2016
... plaque begins early in childhood. Previous reports have shown that GHD children are prone to increased CV risks including impaired cardiac function, dyslipidemia and abnormalities in body composition. Recent studies in epigenetics and metabolomics have defined specific fingerprints that might...
Journal Articles
Journal Articles
Hormone Research (2009) 71 (Suppl. 2): 30–35.
Published Online: 29 April 2009
... disturbances have recently been identified in transient neonatal diabetes mellitus, uniparental disomy (14) syndromes and Silver- Russell syndrome (SRS). Among these diseases, the growth retardation disorder SRS is unique because it is the first human disorder associated with epigenetic mutations that affect...
Journal Articles
Hormone Research (2009) 71 (Suppl. 2): 22–29.
Published Online: 29 April 2009
...Gavin Kelsey The hallmarks of epigenetics – the memory of defining earlier developmental events and the distinction of active and inactive genes – are exemplified by imprinted genes. In this article, I shall consider the imprinted Gnas locus in some detail. Gnas encodes the stimulatory G-protein...
Journal Articles
Hormone Research (2009) 71 (Suppl. 1): 13–16.
Published Online: 21 January 2009
...Robert A. Waterland Background: Epigenetic mechanisms provide one potential explanation for how environmental influences in early life cause long-term changes in chronic disease susceptibility. Whereas epigenetic dysregulation is increasingly implicated in various rare developmental syndromes...
Journal Articles
Hormone Research (2006) 65 (Suppl. 3): 50–58.
Published Online: 10 April 2006
... and nutrient transporter abundance. In turn, epigenetic modification of imprinted genes via changes in DNA methylation may provide a mechanism linking environmental cues to placental phenotype, with consequences for development both before and after birth. Changes in expression of imprinted genes, therefore...