...Svetlana Lajic; Leif Karlsson; Anna Nordenström Prenatal treatment of congenital adrenal hyperplasia with dexamethasone (DEX) has been in use since the mid-1980s and has proven effective at reducing virilization of external genitalia in affected girls. However, multiple experimental studies...

... GC therapy is controversial because of possible adverse effects on fetal programming, the cardiovascular system and the brain. Case Reports: We report 2 patients with congenital adrenal hyperplasia (CAH) due to 21-OHD who were treated prenatally with dexamethasone, suffered from an acute...

... (PRED) or dexamethasone (DEX) during the induction phase of therapy. Methods: A double-blind comparative study of patients treated with PRED and DEX was performed. Sixteen patients received PRED (40 mg/m 2 /day) and 13 patients received DEX (6 mg/m 2 /day), both for 28 days. A low-dose...

... with BMI above the 95th percentile (male:female ratio 7:12) aged from 9.5 to 15.5 years. Patients underwent a 12-week physical exercise program. Before and after exercise, in vivo glucocorticoid sensitivity was determined by employing a very-low-dose intravenous dexamethasone suppression test, and in vitro...

... before and after the training period. Results: Prolonged physical exercise reduced the basal cortisol levels and the percent cortisol reduction after dexamethasone. These findings were associated with a significant reduction in the mRNA levels of GR (6.3%), NFkB1 (63%), inhibitor of NFkB1 (25%) and IkB...

...Ana-Cláudia A.R. Pinto; Roberta F.V.B. Weffort; Fernanda B. Di Ninno; Ana-Maria J. Lengyel Acute dexamethasone administration (2 mg/m 2 i.v. and 4 mg orally) increases growth hormone (GH) release in children. We evaluated the effect of a low intravenous dose (1 mg/m 2 ) of dexamethasone on GH...

...Jane Garland; Athanasios P. Zis In order to further examine the possible role of endogenous opioid peptides and vasopressin in the phenomenon of dexamethasone nonsuppression, we studied the effect of naloxone, vasopressin, and vasopressinnaloxone combination on cortisol secretion following...

..., with or without loss of diurnal rhythm, within 24 h of stopping maintenance glucocorticoid therapy. A single dose of dexamethasone (0.01 mg/kg) given either intravenously or orally at 09.00 h resulted in rapid onset of complete pituitary-adrenal suppression characterised by a prompt and exponential fall in 17P...

... min after dexamethasone. There was a significant increase in NE and E secretion (p < 0.002) from both adrenal glands after ACTH stimulation. In the patient with Cushing’s syndrome, there was also a slight increase in plasma E levels after dexamethasone. It is postulated that ACTH stimulated NE...

...Barry M. Sherman; Janet A. Schlechte; Bruce M. Pfohl We examined the plasma cortisol and ACTH concentrations after graded doses of dexamethasone in a group of young, healthy adults. The decrease in cortisol was uniform in all subjects, and in 8 subjects there was a high degree of correspondence...

...S. Feldman; N. Conforti To elucidate the role of limbic structures in the negative feedback regulation of corticoids of adrenocortical function, the effect of dexamethasone on adrenocortical responses to ether stress was studied in intact and lesioned rats. In animals with septal and preoptic...

... also carried out: ACTH stimulation was found to increase Δ4, DHA and 11βOHΔ4. Dexamethasone had a reverse effect causing a 50% diminution in Δ4 levels, a marked decrease in DHA levels, and a 90% decrease in 11βOHΔ4 levels. Metyrapone test was found to produce a 223 % increase in Δ4 levels, a 196...

... that the adrenal uptake was specific. Pretreatment with dexamethasone decreased the adrenal uptake of 125 I and caused adrenal atrophy. Chronic ACTH treatment increased the size of the adrenals, but did not affect the adrenal uptake of 125 I. These experiments demonstrate selective uptake of 125 I by the adrenals...

... daily dexamethasone, 0.25–0.75 mg/day. The potency of this glucocorticoid in suppressing adrenal steroid biosynthesis relative to cortisol is about 80:1. The onset of regular, ovulatory menstrual cycles, as judged by daily salivary progesterone profiles, was achieved within 2–3 years of menarche using...

...Y. Taché; P. Du Ruisseau; J.R. Ducharme; R. Collu The influence of dexamethasone treatment on the basal values of corticosterone, GH, prolactin (PRL), LH and FSH, as well as on the adenohypophyseal hormone response to chronic stress was studied in female rats. Dexamethasone acetate (25 µg/100 b.w...

...P.A. Desaulles; J. Samsel The systemic and local effects of three corticosteroids and their derivatives dexamethasone pivalate, triamcinolone acetonide and 6α-fluorotriamcinolone acetonide on inflammatory reactions (cotton-pellet granuloma), the weight of the adrenal and thymus, and on body weight...

...P.L. Barthe; P.A. Desaulles The ACTH stimulation test for depot preparations was carried out with a synthetic depot corticotrophin (Synacthen Depot®) in normal, dexamethasone-blocked, and hypophysectomised rats. It was found that the response curves (plasma and adrenal corticosterone) were very...

... increased proportionally to the severity of cold. Acute stimulation of ACTH secretion by exposure to a stressful situation (electrical shocks) did not alter the TSH response to cold. Conversely, acute blockade of the pituitary-adrenocortical response by dexamethasone treatment did not enhance the TSH...

..., play a role in the pathogenesis of hirsutism. Dexamethasone and estrogen progestin combinations were administered for dynamic tests, and results in most cases provided useful information in the selection of suitable long-term therapy. 21 11 2008 Hormone Res. 7: 16 27 (1976) Simultaneous...

... to corticotherapy suggests a role for individual recognition of steroid sensitivity in order to customize treatment. Oral dexamethasone (DEX) administration may be hindered by the rate of its intestinal absorption and the liver first-passage effect. In this study we suggest that an intravenous very low dose DEX...