.... A recent study in newborns and children showed different miRNA expression levels dependent on different developmental stages [ 19 ]. In particular, 36 miRNAs increased from birth to mid-childhood. These miRNAs targeted genes involved in pathways associated with post-translational modifications, metabolism...

..., instructions or products referred to in the content or advertisements. Androgens Treatment Development Delayed puberty in boys is defined as the absence of testicular enlargement over 4 mL after the age of 14 years or greater than 2 SD later than the population mean [ 1 ]. It is a common...

... to be upregulated, leading to alterations in growth and developmental pathways, and, ultimately, to deleterious health consequences. ...

... testing [ 34,38,40 ]. Pregnant women, and more generally women at a fertile age, are by far the most critical population as regards susceptibility to ED. Indeed, scientific evidence points out a high susceptibility during pregnancy and prenatal development. Typically, ED elicit ‘delayed developmental...

... of the gene or protein appear to result in diseases affecting both pituitary gland development and physiology and the nervous systems (causing limited neck rotation, deafness, developmental delay, etc.). The T194R mutation described here falls into this class. Similarly, the A210V missense mutation apparently...

... altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia 2004;47:1831–1837. 33. Armitage JA, Taylor PD, Poston L: Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J...

... that are characteristic of MC4R rare coding mutations [ 5 ]. The heritability of fat mass is estimated to be between 25 and 71% [ 8,9 ] suggesting that its developmental accretion has both genetic and environmental components. Both fetal [ 10 ] and early postnatal [ 11 ] weight gain are linked with the risk...

... important for prenatal counselling are the neurocognitive and developmental aspects of KS. Patients with KS are reported to have mild cognitive impairment, especially in relation to verbal tasks, and difficulties in school [ 7, 31, 32 ]. The retrospective nature of our study made us restrict our analyses...

... during their normal course of development [1-4], Such programmed death of embryonic cells occurs at a specific location and a predictable developmental time. During the development of limbs in reptiles, birds and mammals, the occurrence of cell death at predictable regions has been described [5...

.... Data from study of type 1 IGF receptor (IGF 1R) knockout mice indicate that this receptor mediates most IGF-I and IGF-II growth-promoting actions. The central importance of the IGFs and the IGF 1R to development is underscored by the fact that IGF 1R knockout mice do not survive past birth. Our more...

... the findings that IGF-1 IG F-lR double mutants do not differ in phenotype from IGF-1R single mutants (45% of nor­ mal size), whereas IGF-2 (pIGF-lR double mu­ tants are growth retarded further (30% of normal size). F14 F16 F18 Age (Days) N6 Fig. 1. Developmental profile of GHR and GHBP mRNAs in mouse liver...

... and Clinical Aspects Horm Res 1995;43:162-167 C.A. Stratakis'AC P W. Goldb G.P. Chrousosa Developmental Endocrinology Branch, National Institute of Child Health and Human Development, and Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Md USA...

.... There are at least two general mechanisms by which metabolic signals could modulate the central drive to the reproductive axis. One possibility is that changes in the body s metabolic state (associated with periods of altered nutrition or with developmental changes in metabolic rate) could provide a signal...

..., Department of Pediatrics and Genetics, and Department of Gynecology and Obstetrics, Canton University Hospital, Geneva, Switzerland Key Words. Androgen Metabolism Genital skin HPLC 17p-Hydroxysteroid dehydrogenase 5a-Reductase Development Abstract. The normal developmental pattern of 17P...

... among the many rhythms in an individual) is formed. At the present the best system available for a study of the developmental events that lead to the appearance of overt rhythmicity is the neural regulation of the pineal gland. Other developing systems about which much is known with respect to circadian...

.... Activation of the receptor in the fetal and neonatal periods in rodents evokes important growth and development actions. Tissue EGF and EGF receptor concentrations are modulated by thyroid hormones, estrogen, testosterone and growth hormone, suggesting that selected growth and developmental actions...

... paediat. scand. 277: 41-46 (1980). 7 Fisher, D.A.; Klein, A.H.: Thyroid development and disorders of thyroid function in newborn. New Engl. J. Med. 304: 702-712 (1981). 8 Dobbing, J.: Undernutrition and the developing brain. Am. J. Dis. Child. 120: 411-415 (1974). 9 Eayrs, J.T.: Developmental...

..., instructions or products referred to in the content or advertisements. Thymulin Thyroid hormones Neuroendocrinology Development Aging Horm Res 1989;31:85-89 © 1989 S. Karger AG, Basel 0301-0163/89/0312-0085S2.75/0 Thyroid-Thymus Interactions during Development and Aging N. Fabrisa, E. Mocchegiania...

... Development Strain differences Seasonality Gonadotropins Prolactin Androgens Corticosterone Abstract. The influence of age, strain and season on the circadian pattern of serum levels of LH, FSH, prolactin, androgens and corticosterone was studied in five groups of male labora­ tory rats...

... of the immature rat. Endocri­ nology 68: 115-120(1961). 2 Divila, F.; Presl, J.; Krabec, Z., and Horsky, J.: Developmental changes in the ovulatory and secretory response to a single dose of HCG in the rat. Physiologia bohemoslov. 20: 364-365 (1971). 3 Gilman, A.G.: A protein binding assay for adenosine 3',5...