...Yuji Hiromatsu; Pei Wen Wang; Len Wosu; Jacques How; Jack R. Wall We have studied the role of immunologically mediated cytotoxicity in the orbital tissue damage of Graves’ ophthalmopathy. Antibody-dependent cell-mediated cytotoxicity (ADCC) against eye muscle (EM) cells and orbital fibroblasts...

... of growth factors (EGF, insulin). At concentrations ≤ 4 µ M , antiestrogens are also cytotoxic and they require accessible estrogen receptors for their action. ‘Estrogen-receptor-targeted drugs’ is therefore a better general term than ‘antiestrogens’ to describe the mechanism of action of these drugs, which...